Effect of Qing’e Decoction on LeptinLeptin Receptor and Bone Metabolism in Naturally Aging Rats
المؤلفون المشاركون
Wang, Zhiqiang
Zhang, Yuanyuan
Sun, Pan
Wei, Zhenpu
Guo, Shiming
Lin, Yanping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Senile osteoporosis (SOP) is a common disease that has decreased bone strength as its main symptom.
There is currently no medication that can treat SOP, and traditional Chinese medicine has advantages in slowing down bone aging.
The present study aimed to observe the effects of Qing’e decoction on leptin, leptin receptor, sex hormone, and biochemical markers of bone metabolism in naturally aging rats and to explore its mechanism in regulating bone metabolism.
The results revealed that, with the increase in age, the bone mineral density (BMD), bone strength, bone trabecula sparse, serum levels of leptin receptor (LEP-R), estradiol (E2), testosterone (T), core binding-factor α-1 (Cbfα-1), collagen-I (COL-I) and osteocalcin (OC), and the mRNA levels of leptin (LEP) and LEP-R in bone tissue decreased, while serum LEP levels increased in the female and male NS groups.
The serum levels of LEP, LEP-R, E2, T, osteoprotegerin, Cbfα-1, COL-I, OC and bone alkaline phosphatase, and the mRNA levels of LEP and LEP-R in bone tissue in the female and male QED groups were higher than those in the same age and sex NS group, while the BMD, bone trabecular area percentage, maximum load, and maximum stress in the female and male QED groups were significantly higher than those in the same age and sex NS group.
In conclusion, with the increase in age, the bone quality of naturally aging rats decreased gradually.
Qing’e decoction can regulate the bone metabolism and increase the bone quality and delay bone aging, which may be achieved by increasing sex hormone, LEP, and LEP-R levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Pan& Zhang, Yuanyuan& Wei, Zhenpu& Wang, Zhiqiang& Guo, Shiming& Lin, Yanping. 2020. Effect of Qing’e Decoction on LeptinLeptin Receptor and Bone Metabolism in Naturally Aging Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155267
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Pan…[et al.]. Effect of Qing’e Decoction on LeptinLeptin Receptor and Bone Metabolism in Naturally Aging Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1155267
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Pan& Zhang, Yuanyuan& Wei, Zhenpu& Wang, Zhiqiang& Guo, Shiming& Lin, Yanping. Effect of Qing’e Decoction on LeptinLeptin Receptor and Bone Metabolism in Naturally Aging Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155267
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155267
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر