Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine
المؤلفون المشاركون
Shim, Bum Sang
Jeon, Hyeonjin
Eo, Wankyu
Kim, Sehyun
Lee, Sookyung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
The impact of health-related quality of life (HRQoL) on survival has been investigated in patients with various cancers.
Here, we evaluated the prognostic value of HRQoL using the Functional Assessment of Cancer Therapy-General (FACT-G) in advanced non-small-cell lung cancer (NSCLC) patients treated with Korean medicine.
Methods.
A retrospective review of medical records and FACT-G scores of patients with advanced NSCLC who received treatment with Korean medicine was conducted.
The reliability of the FACT-G was determined using Cronbach’s alpha and calculating floor-and-ceiling effects.
Correlations between FACT-G scores were estimated using Pearson’s correlation analysis.
Overall survival was calculated using the Kaplan–Meier method, and the prognostic impact of FACT-G scores and patients’ characteristics was evaluated with Cox proportional hazards regression.
Results.
Of the 165 enrolled patients, 115 (70%) had extrathoracic metastasis and 139 (84%) had undergone prior anticancer treatment.
The median overall survival was 10.1 months.
The mean FACT-G score was 65.0, and Cronbach’s alpha for the FACT-G was 0.917.
Age ≥65 years, male sex, smoking history, squamous-cell carcinoma, Eastern Cooperative Oncology Group Performance Status (ECOG-PS) ≥2, and presence of extrathoracic metastasis were associated with an increased risk of mortality.
High FACT-G total scores, physical well-being (PWB), emotional well-being, and functional well-being were associated with prolonged survival.
After adjusting for age, sex, smoking history, ECOG-PS, histological type, and presence of extrathoracic metastasis, a high FACT-G total score (hazard ratio (HR): 0.99, p=0.032) and high PWB score (HR: 0.94, p<0.001) were associated with prolonged survival as independent prognostic factors in patients with advanced NSCLC.
Conclusion.
The FACT-G total score and PWB score as HRQoL measurements were significant prognostic factors for survival in advanced NSCLC patients treated with Korean medicine.
This finding implies that the FACT-G can be used in clinical practice as a predictor of survival in patients with advanced NSCLC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jeon, Hyeonjin& Eo, Wankyu& Shim, Bum Sang& Kim, Sehyun& Lee, Sookyung. 2020. Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155447
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jeon, Hyeonjin…[et al.]. Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155447
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jeon, Hyeonjin& Eo, Wankyu& Shim, Bum Sang& Kim, Sehyun& Lee, Sookyung. Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155447
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155447
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر