Effects of 4-Week Intervention with Ulmus macrocarpa Hance Extract on Immune Function Biomarkers in Healthy Adults: A Randomized Controlled Trial
المؤلفون المشاركون
Lee, Sang Yeoup
Kim, Cheol Min
Cho, A Ra
Kim, Sung Goo
Cho, Younghye
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Ulmus macrocarpa extract has been shown to have immune-related effects in animals, but no studies have yet been performed in humans.
This randomized, double-blind, placebo-controlled trial was conducted to determine the effect of short-term administration of Ulmus macrocarpa Hance extract (UME) on immune function biomarkers and its safety in human subjects.
Fifty-eight subjects were randomly assigned to a UME group or a placebo group.
Subjects in the UME group were given 500 mg per day of UME orally for 4 weeks.
Mean fluorescence intensity (MFI) of tumor necrotic factor-α increased only in the UME group at 1 week (P=0.027).
The MFI of interleukin-2 decreased less significantly in the UME group than in the placebo group at 1 week (P=0.028).
However, unfortunately, at 4 weeks, no intergroup differences were detected in MFIs of cytokine.
In conclusion, administration of UME for 1 week increased serum TNF-α and sustains IL-2 in human, which suggests that UME increases Th1-related immune function in the short term in healthy people.
However, additional studies are needed to confirm the results of this first-stage study and further trials are required to decide on optimal dosage and duration of administration.
This trial is registered with ClinicalTrials.gov Identifier: NCT02414412.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cho, A Ra& Lee, Sang Yeoup& Cho, Younghye& Kim, Cheol Min& Kim, Sung Goo. 2018. Effects of 4-Week Intervention with Ulmus macrocarpa Hance Extract on Immune Function Biomarkers in Healthy Adults: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1155587
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cho, A Ra…[et al.]. Effects of 4-Week Intervention with Ulmus macrocarpa Hance Extract on Immune Function Biomarkers in Healthy Adults: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1155587
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cho, A Ra& Lee, Sang Yeoup& Cho, Younghye& Kim, Cheol Min& Kim, Sung Goo. Effects of 4-Week Intervention with Ulmus macrocarpa Hance Extract on Immune Function Biomarkers in Healthy Adults: A Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1155587
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155587
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر