The Traditional Chinese Medicine Fufang Shatai Heji (STHJ)‎ Enhances Immune Function in Cyclophosphamide-Treated Mice

المؤلفون المشاركون

Fan, Kai-Jian
Li, Yun-Wu
Wu, Jing
Li, Jun
Zhang, Jun
Wang, Qi-Shan
Xu, Bing-Xin
Cai, Qing
Wang, Ting-Yu

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-01-23

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Fufang Shatai Heji (STHJ) is a mixture of traditional Chinese medicines, such as Radix Adenophorae, Radix Pseudostellariae, and Radix Astragali.

STHJ is commonly used to treat diseases caused by low immune function, for example, Sjögren’s syndrome (SS).

The primary objective of this study was to assess the immunopotentiating effect of STHJ using an immunosuppressive mouse model receiving cyclophosphamide (CTX).

Following CTX treatment, STHJ was administered by oral gavage for 30 consecutive days.

The percentage of specific lymphocyte subpopulations in the spleen was measured by flow cytometry.

Levels of inflammatory factors in serum were detected by enzyme-linked immunosorbent assays (ELISAs).

The administration of STHJ significantly elevated thymus and spleen indices, increased B cell and natural killer (NK) cell activities, and decreased CD8+ T, CD8+CD122+ T, NKT, and γδT cell activities in the CTX-treated mice.

In addition, STHJ upregulated the expression of interleukin- (IL-) 2, IL-6, and tumor necrosis factor-α (TNF-α) and downregulated IL-10 expression in CTX-treated mice.

In conclusion, STHJ effectively remitted CTX-induced immunosuppression by modulating the balance of lymphocyte subsets and cytokines.

Our results suggest STHJ treatment could be used as an effective therapeutic approach to improve immune function in patients with low immunity.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Fan, Kai-Jian& Li, Yun-Wu& Wu, Jing& Li, Jun& Zhang, Jun& Wang, Qi-Shan…[et al.]. 2020. The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155964

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fan, Kai-Jian…[et al.]. The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1155964

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Fan, Kai-Jian& Li, Yun-Wu& Wu, Jing& Li, Jun& Zhang, Jun& Wang, Qi-Shan…[et al.]. The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155964

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1155964