First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin
المؤلفون المشاركون
Sue, Soichiro
Maeda, Shin
Suzuki, Nobumi
Sasaki, Tomohiko
Yamada, Hiroaki
Kaneko, Hiroaki
Tamura, Toshihide
Ishii, Tomohiro
Kondo, Masaaki
Shibata, Wataru
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
To assess the efficacy of 7-day first-line Helicobacter pylori eradication with vonoprazan (VPZ), clarithromycin (CAM), and metronidazole (MNZ) in patients with penicillin allergy.
Methods.
Patients with penicillin allergy, diagnosed with Helicobacter pylori infection and did not have history of Helicobacter pylori eradication, were eligible for the study.
Twenty patients were prospectively treated with 20 mg VPZ twice daily, 200 or 400 mg CAM twice daily, and 250 mg MNZ twice daily for 7 days.
We also collected the data from 30 patients retrospectively treated with proton pump inhibitor (PPI), CAM, and MNZ.
Safety was evaluated in patients completing an adverse effect questionnaire.
Results.
Both the intention-to-treat and per-protocol effectiveness of VPZ-based eradication were 100% (95% CI: 86.1–100%; n=20).
The eradication rates of PPI-based regimen were 83.3% (95% CI: 65.3–94.4%) in the ITT and 82.7% (95% CI: 64.2–94.2%) in the PP analyses.
Abdominal fullness was more frequent in VCM compared to PCM.
However, all patients with VCM regimen had taken 100% of their course of medication.
Conclusion.
Triple therapy with VPZ, CAM, and MNZ is well tolerated and effective for eradicating Helicobacter pylori in patients allergic to penicillin.
This study was registered in the UMIN Clinical Trials Registry as UMIN000016335.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sue, Soichiro& Suzuki, Nobumi& Shibata, Wataru& Sasaki, Tomohiko& Yamada, Hiroaki& Kaneko, Hiroaki…[et al.]. 2017. First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sue, Soichiro…[et al.]. First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin. Gastroenterology Research and Practice No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1156216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sue, Soichiro& Suzuki, Nobumi& Shibata, Wataru& Sasaki, Tomohiko& Yamada, Hiroaki& Kaneko, Hiroaki…[et al.]. First-Line Helicobacter pylori Eradication with Vonoprazan, Clarithromycin, and Metronidazole in Patients Allergic to Penicillin. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1156216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر