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Neuronal Specificity of Acupuncture in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Functional MRI Study
المؤلفون المشاركون
Shan, Yi
Wang, Zhi-qun
Zhang, Mo
Han, Ying
Li, Kuncheng
Wang, Jing-Juan
Xu, Jian-Yang
Zhao, Zhilian
Lu, Jie
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-17
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Although acupuncture is considered to be effective and safe for Alzheimer’s disease (AD) and mild cognitive impairment (MCI), the mechanism underlying its therapeutic effect is still unknown.
Most studies clarifying the neuronal pathway produced by acupuncture were still applied to healthy subjects with limited single acupuncture point stimulation, which was inconsistency with clinical practice.
Thus, in our present study, we investigate the differences between brain activity changes in AD and MCI patients caused by multi-acupuncture point Siguan (four gates), in order to provide visualized evidence for neuronal specificity of clinical acupuncture.
Forty-nine subjects were recruited, including 21 AD patients, 14 MCI patients, and 14 healthy controls (HC).
AD and MCI patients were randomly divided into two groups, respectively: real acupuncture point group (14 AD and 8 MCI) and sham acupuncture point group (7 AD and 6 MCI).
We adopted a 16-minute, single-block, experimental design for acquiring functional MRI images.
We found, in AD and MCI patients, Siguan (four gates) elicited extensive activations and deactivations in cognitive-related areas, visual-related areas, the sensorimotor-related area, basal ganglia, and cerebellum.
Compared with HC, AD and MCI patients showed similar activations in cognitive-related brain areas (inferior frontal gyrus, supramarginal gyrus, and rolandic operculum) as well as deactivations in cognitive-related areas, visual-related areas, basal ganglia, and cerebellum, which were not found in HC.
Compared with sham acupuncture points, real acupuncture points produced more specific brain changes with both activated and deactivated brain activities in AD and MCI.
The preliminary results in our study verified the objective evidence for neuronal specificity of acupuncture in AD and MCI patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shan, Yi& Wang, Jing-Juan& Wang, Zhi-qun& Zhao, Zhilian& Zhang, Mo& Xu, Jian-Yang…[et al.]. 2018. Neuronal Specificity of Acupuncture in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Functional MRI Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156256
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shan, Yi…[et al.]. Neuronal Specificity of Acupuncture in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Functional MRI Study. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156256
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shan, Yi& Wang, Jing-Juan& Wang, Zhi-qun& Zhao, Zhilian& Zhang, Mo& Xu, Jian-Yang…[et al.]. Neuronal Specificity of Acupuncture in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Functional MRI Study. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156256
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156256
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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