Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties
المؤلفون المشاركون
Stabili, Loredana
Acquaviva, Maria Immacolata
Cavallo, Rosa Anna
Gerardi, Carmela
Narracci, Marcella
Pagliara, Patrizia
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Echinoderms are a renewable resource with an economic value due to their increasing demand as food and/or source of bioactive molecules exerting antitumor, antiviral, anticoagulant, antioxidant, and antimicrobial activities.
In this framework, the present study is aimed at investigating the antibacterial, antioxidant, and hemolytic activities in the three Echinoderm species Echinaster sepositus, Arbacia lixula, and Sphaerechinus granularis.
The sea star E.
sepositus showed lysozyme-like activity (mean diameter of lysis of 13.4±0.2 mm), an antimicrobial activity against the human emerging pathogens Staphylococcus aureus, Pseudomonas aeruginosa, and Candida famata, and a strong lytic activity (100±0.05%) towards the human red blood cells.
Furthermore A.
lixula and E.
sepositus had the highest antioxidant activity (1792.75±233.7 and 1765.65±484.58 nmolTE/mL, resp.).
From toxicological assays, it was shown that E.
sepositus was not toxic towards HeLa cells and Vibrio fischeri, encouraging the exploitation of this species in the pharmaceutical field.
Therefore, our findings have implications due to the ongoing explosion of antibiotic-resistant infections because of the new opportunistic pathogens and the need to discover antibacterial agents with new modes of action.
Also the recorded antioxidant activity taking into account the need to find natural antioxidants useful for human health is intriguing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stabili, Loredana& Acquaviva, Maria Immacolata& Cavallo, Rosa Anna& Gerardi, Carmela& Narracci, Marcella& Pagliara, Patrizia. 2018. Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156306
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stabili, Loredana…[et al.]. Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156306
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stabili, Loredana& Acquaviva, Maria Immacolata& Cavallo, Rosa Anna& Gerardi, Carmela& Narracci, Marcella& Pagliara, Patrizia. Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156306
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156306
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر