Ginsenoside Re Attenuates Isoproterenol-Induced Myocardial Injury in Rats
المؤلفون المشاركون
Yu, Xiao-feng
Xu, Hua-li
Zhao, Xue-zhong
Sui, Da-yuan
Jiang, Yichuan
Wang, Quan-wei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Panax ginseng is widely used for treatment of cardiovascular disorders in China.
Ginsenoside Re is the main chemical component of Panax ginseng.
This study aimed to investigate the protective effect of Ginsenoside Re on isoproterenol-induced myocardial injury in rats.
Methods.
Male Wistar rats were orally given Ginsenoside Re (5, 20 mg/kg) daily for 7 days.
Isoproterenol was subcutaneously injected into the rats for two consecutive days at a dosage of 20 mg/kg/day (on 6th and 7th day).
Six hours after the last isoproterenol injection, troponin T level and creatine kinase-MB (CK-MB) activity were assayed.
Histopathological examination of heart tissues was performed.
The levels of malondialdehyde (MDA) and glutathione (GSH) in heart tissues were measured.
The nuclear factor erythroid 2-related factor 2 (Nrf2) content in nucleus and the proteins of glutathione cysteine ligase catalytic subunit (GCLC) and glutathione cysteine ligase modulatory subunit (GCLM) in heart tissues were assayed by western blotting method.
Results.
Treatment with Ginsenoside Re at dose of 5, 20 mg/kg reduced troponin T level and CK-MB activity of rats subjected to isoproterenol.
The cardioprotective effect of Ginsenoside Re was further confirmed by histopathological examination which showed that Ginsenoside Re attenuated the necrosis and inflammatory cells infiltration.
Ginsenoside Re inhibited the increase of MDA content and the decrease of GSH in heart tissues.
Moreover, the Nrf2 content in nucleus and the expressions of GCLC and GCLM were significantly increased in the animals treated with Ginsenoside Re.
Conclusion.
These findings suggested that Ginsenoside Re possesses the property to attenuate isoproterenol-induced myocardial ischemic injury by regulating the antioxidation function in cardiomyocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Quan-wei& Yu, Xiao-feng& Xu, Hua-li& Jiang, Yichuan& Zhao, Xue-zhong& Sui, Da-yuan. 2018. Ginsenoside Re Attenuates Isoproterenol-Induced Myocardial Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156680
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Quan-wei…[et al.]. Ginsenoside Re Attenuates Isoproterenol-Induced Myocardial Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1156680
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Quan-wei& Yu, Xiao-feng& Xu, Hua-li& Jiang, Yichuan& Zhao, Xue-zhong& Sui, Da-yuan. Ginsenoside Re Attenuates Isoproterenol-Induced Myocardial Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1156680
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156680
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر