Cardiac CaMKIIδ and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells
المؤلفون المشاركون
Chen, Yu
Li, Xinye
An, Na
Song, Ke
Xing, Yanfen
Wu, Honghua
Gao, Xiongyi
Chen, Hengwen
Pan, Xiandu
He, Xiaofang
Gao, Yonghong
Xing, Yanwei
Li, Yuanyuan
Li, Yang
Wang, Xin
Yang, Fan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-23
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Previous studies have demonstrated that calcium-/calmodulin-dependent protein kinase II (CaMKII) and calcineurin A-nuclear factor of activated T-cell (CnA-NFAT) signaling pathways play key roles in cardiac hypertrophy (CH).
However, the interaction between CaMKII and CnA-NFAT signaling remains unclear.
H9c2 cells were cultured and treated with angiotensin II (Ang II) with or without silenced CaMKIIδ (siCaMKII) and cyclosporine A (CsA, a calcineurin inhibitor) and subsequently treated with Wenxin Keli (WXKL).
Patch clamp recording was conducted to assess L-type Ca2+ current (ICa-L), and the expression of proteins involved in signaling pathways was measured by western blotting.
Myocardial cytoskeletal protein and nuclear translocation of target proteins were assessed by immunofluorescence.
The results indicated that siCaMKII suppressed Ang II-induced CH, as evidenced by reduced cell surface area and ICa-L.
Notably, siCaMKII inhibited Ang II-induced activation of CnA and NFATc4 nuclear transfer.
Inflammatory signaling was inhibited by siCaMKII and WXKL.
Interestingly, CsA inhibited CnA-NFAT pathway expression but activated CaMKII signaling.
In conclusion, siCaMKII may improve CH, possibly by blocking CnA-NFAT and MyD88 signaling, and WXKL has a similar effect.
These data suggest that inhibiting CaMKII, but not CnA, may be a promising approach to attenuate CH and arrhythmia progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
An, Na& Chen, Yu& Xing, Yanfen& Wu, Honghua& Gao, Xiongyi& Chen, Hengwen…[et al.]. 2020. Cardiac CaMKIIδ and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1158539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
An, Na…[et al.]. Cardiac CaMKIIδ and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1158539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
An, Na& Chen, Yu& Xing, Yanfen& Wu, Honghua& Gao, Xiongyi& Chen, Hengwen…[et al.]. Cardiac CaMKIIδ and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1158539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر