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Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites
المؤلفون المشاركون
Burra, Patrizia
Tikhonoff, Valérie
Russo, Francesco Paolo
Ferrarese, Alberto
Angeli, Paolo
Fasolato, Silvano
Faggian, Diego
Zanetto, Alberto
Germani, Giacomo
Senzolo, Marco
Casiglia, Edoardo
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Nonselective β-blockers (NSBB) have been associated with increased incidence of paracentesis-induced circulatory dysfunction (PICD) and reduced survival in patients with cirrhosis and refractory ascites.
Aim.
To prospectively evaluate a hemodynamic response to NSBB in cirrhotics listed for liver transplantation with refractory ascites undergoing large volume paracentesis (LVP).
Methods.
Patients with cirrhosis and refractory ascites, with an indication to start NSBB in primary prophylaxis for variceal bleeding, were enrolled.
During two consecutive LVP, while being, respectively, off and on NSBB, cardiac output (CO), systemic vascular resistances (SVR), peripheral vascular resistances (PVR), and plasma renin activity (PRA) were noninvasively assessed.
Results.
Seventeen patients were enrolled, and 10 completed the study.
Before NSBB introduction, SVR (1896 to 1348 dyn·s·cm−5; p=0.028) and PVR (47 to 30 mmHg·min·dl·ml−1; p=0.04) significantly decreased after LVP, while CO showed an increasing trend (3.9 to 4.5 l/m; p=0.06).
After NSBB introduction, LVP was not associated with a significant increase in CO (3.4 to 3.8 l/m; p=0.13) nor with a significant decrease in SVR (2002 versus 1798 dyn·s·cm−5; p=0.1).
Incidence of PICD was not increased after NSBB introduction.
Conclusion.
The negative inotropic effect of NSBB was counterbalanced by a smaller decrease of vascular resistances after LVP, probably due to splanchnic β2-blockade.
This pilot study showed that NSBB introduction may be void of detrimental hemodynamic effects after LVP in cirrhotics with refractory ascites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferrarese, Alberto& Tikhonoff, Valérie& Casiglia, Edoardo& Angeli, Paolo& Fasolato, Silvano& Faggian, Diego…[et al.]. 2018. Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159602
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferrarese, Alberto…[et al.]. Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159602
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferrarese, Alberto& Tikhonoff, Valérie& Casiglia, Edoardo& Angeli, Paolo& Fasolato, Silvano& Faggian, Diego…[et al.]. Hemodynamic Evaluation of Nonselective β-Blockers in Patients with Cirrhosis and Refractory Ascites. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159602
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1159602
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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