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Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii
المؤلفون المشاركون
Souza, Érica Simplício
Cruz, Kátia Santana
Lima, Emerson Silva
Silva, Marcia de Jesus Amazonas da
Montoia, Andreia
Souza, João Vicente Braga de
Pohlit, Adrian Martin
المصدر
International Journal of Microbiology
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Cryptococcosis is a fungal disease of bad prognosis due to its pathogenicity and the toxicity of the drugs used for its treatment.
The aim of this study was to investigate the medicinal potential of carbazole and β-carboline alkaloids and derivatives against Cryptococcus neoformans and C.
gattii.
Methods.
MICs were established in accordance with the recommendations of the Clinical and Laboratory Standards Institute for alkaloids and derivatives against C.
neoformans and C.
gattii genotypes VNI and VGI, respectively.
A single active compound was further evaluated against C.
neoformans genotypes VNII, VNIII, and VNIV, C.
gattii genotypes VGI, VGIII, and VGIV, Candida albicans ATCC 36232, for cytotoxicity against the MRC-5 lineage of human fibroblasts and for effects on fungal cells (cell wall, ergosterol, and leakage of nucleic acids).
Results.
Screening of 11 compounds revealed 8-nitroharmane as a significant inhibitor (MIC 40 μg/mL) of several C.
neoformans and C.
gattii genotypes.
It was not toxic to fibroblasts (IC50 > 50 µg/mL) nor did it alter fungal cell walls or the concentration of ergosterol in C.
albicans or C.
neoformans.
It increased leakage of substances that absorb at 260 nm.
Conclusions.
The synthetic β-carboline 8-nitroharmane significantly inhibits pathogenic Cryptococcus species and is interesting as a lead compound towards new therapy for Cryptococcus infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cruz, Kátia Santana& Lima, Emerson Silva& Silva, Marcia de Jesus Amazonas da& Souza, Érica Simplício& Montoia, Andreia& Pohlit, Adrian Martin…[et al.]. 2019. Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii. International Journal of Microbiology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cruz, Kátia Santana…[et al.]. Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii. International Journal of Microbiology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1166281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cruz, Kátia Santana& Lima, Emerson Silva& Silva, Marcia de Jesus Amazonas da& Souza, Érica Simplício& Montoia, Andreia& Pohlit, Adrian Martin…[et al.]. Screening and Antifungal Activity of a β-Carboline Derivative against Cryptococcus neoformans and C. gattii. International Journal of Microbiology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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