Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma
المؤلفون المشاركون
Iacobone, Maurizio
Bertazza, Loris
Censi, Simona
Watutantrige-Fernando, Sara
Mian, Caterina
Cavedon, Elisabetta
Barollo, Susi
Galuppini, Francesca
Benna, Clara
Vianello, Federica
Zovato, Stefania
Nacamulli, Davide
Pennelli, Gianmaria
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Little is known about the function of microRNA-224 (miR-224) in medullary thyroid cancer (MTC).
This study investigated the role of miR-224 expression in MTC and correlated it with mutation status in sporadic MTCs.
A consecutive series of 134 MTCs were considered.
Patients had a sporadic form in 80% of cases (107/134).
In this group, REarranged during transfection (RET) and rat sarcoma (RAS) mutation status were assessed by direct sequencing in the tumor tissues.
Quantitative real-time polymerase chain reaction was used to quantify mature hsa-miR-224 in tumor tissue.
RAS (10/107 cases, 9%) and RET (39/107 cases, 36%) mutations were mutually exclusive in sporadic cases.
miR-224 expression was significantly downregulated in patients with the following: high calcitonin levels at diagnosis (p=0.03, r=−0.3); advanced stage (p=0.001); persistent disease (p=0.001); progressive disease (p=0.002); and disease-related death (p=0.0001).
We found a significant positive correlation between miR-224 expression and somatic RAS mutations (p=0.007).
Patients whose MTCs had a low miR-224 expression tended to have a shorter overall survival (log-rank test p=0.005).
On multivariate analysis, miR-224 represented an independent prognostic marker.
Our data indicate that miR-224 is upregulated in RAS-mutated MTCs and in patients with a better prognosis and could represent an independent prognostic marker in MTC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cavedon, Elisabetta& Barollo, Susi& Bertazza, Loris& Pennelli, Gianmaria& Galuppini, Francesca& Watutantrige-Fernando, Sara…[et al.]. 2017. Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cavedon, Elisabetta…[et al.]. Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cavedon, Elisabetta& Barollo, Susi& Bertazza, Loris& Pennelli, Gianmaria& Galuppini, Francesca& Watutantrige-Fernando, Sara…[et al.]. Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر