Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease
المؤلفون المشاركون
Salinas-Carmona, Mario C.
Gongora-Rivera, Fernando
Cordero-Perez, Adolfo
Gonzalez-Aquines, Alejandro
Anaya-Escamilla, Antonio
Villarreal-Garza, Eduardo
Espinosa-Ortega, Meztli
Ortiz-Jimenez, Xochilt
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Recent studies have shown that cerebral vascularity may be impaired in Alzheimer’s disease.
Cerebral vasomotor reactivity could be an important biomarker for this pathology.
Aims.
The aim of this study was to investigate the alterations in cerebral vascular motor reactivity in Alzheimer’s disease subjects and to associate these changes with their cognitive scores.
Methods.
We recruited subjects with a diagnosis of Alzheimer’s disease and healthy controls.
Demographic, clinical, imaging, and cognitive test were obtained.
Then all participants performed a cerebral vascular motor reactivity test with 7% CO2 and cerebral blood flow velocities (CBFV) were recorded with transcranial doppler ultrasound before and after the test.
Results.
We recruited 45 subjects, 26 (21 female) Alzheimer’s disease participants and 19 (15 female) healthy controls.
There were no differences in baseline cerebral blood flow velocities between the groups.
After the cerebral vasomotor reactivity test, absolute mean difference in mean CBFV (ΔCBFV-m) was 8.70±4.14 versus 4.81±6.96 (p<0.01), respectively.
Calculated percentage of change (%CVMR) was lower in the AD group 7.45±18.25 versus 23.29±17.48, and there was a positive but weak correlation with mini-mental scores (ρ=0.337, p=0.023).
Conclusions.
In this study, Alzheimer’s disease subjects showed significant changes in all absolute cerebral blood flow velocities after the cerebral vasomotor reactivity test with CO2, but only diastolic phase responses were statistically significant.
There was a positive but weak correlation between cerebral vasomotor reactivity and cognitive scores.
Further studies are needed to investigate these effects in larger Latin-American samples.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gongora-Rivera, Fernando& Cordero-Perez, Adolfo& Gonzalez-Aquines, Alejandro& Anaya-Escamilla, Antonio& Villarreal-Garza, Eduardo& Espinosa-Ortega, Meztli…[et al.]. 2018. Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1166592
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gongora-Rivera, Fernando…[et al.]. Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1166592
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gongora-Rivera, Fernando& Cordero-Perez, Adolfo& Gonzalez-Aquines, Alejandro& Anaya-Escamilla, Antonio& Villarreal-Garza, Eduardo& Espinosa-Ortega, Meztli…[et al.]. Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1166592
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166592
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر