β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques
المؤلفون المشاركون
Sato, Kengo
Mori, Yusaku
Okano, Taisuke
Shirai, Remina
Seki, Tomomi
Shibata, Koichiro
Yamashita, Tomoyuki
Koide, Ayaka
Tezuka, Hitomi
Hirano, Tsutomu
Watanabe, Takuya
المصدر
International Journal of Endocrinology
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-28
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
β-Endorphin, an endogenous opioid peptide, and its μ-opioid receptor are expressed in brain, liver, and peripheral tissues.
β-Endorphin induces endothelial dysfunction and is related to insulin resistance.
We clarified the effects of β-endorphin on atherosclerosis.
We assessed the effects of β-endorphin on the inflammatory response and monocyte adhesion in human umbilical vein endothelial cells (HUVECs), foam cell formation, and the inflammatory phenotype in THP-1 monocyte-derived macrophages, and migration and proliferation of human aortic smooth muscle cells (HASMCs) in vitro.
We also assessed the effects of β-endorphin on aortic lesions in Apoe−/− mice in vivo.
The μ-opioid receptor (OPRM1) was expressed in THP-1 monocytes, macrophages, HASMCs, HUVECs, and human aortic endothelial cells.
β-Endorphin significantly increased THP-1 monocyte adhesion to HUVECs and induced upregulation of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin via nuclear factor-κB (NF-κB) and p38 phosphorylation in HUVECs.
β-Endorphin significantly increased HUVEC proliferation and enhanced oxidized low-density lipoprotein-induced foam cell formation in macrophages.
β-Endorphin also significantly shifted the macrophage phenotype to proinflammatory M1 rather than anti-inflammatory M2 via NF-κB phosphorylation during monocyte-macrophage differentiation and increased migration and apoptosis in association with c-jun-N-terminal kinase, p38, and NF-κB phosphorylation in HASMCs.
Chronic β-endorphin infusion into Apoe−/− mice significantly aggravated the development of aortic atherosclerotic lesions, with an increase in vascular inflammation and the intraplaque macrophage/smooth muscle cell ratio, an index of plaque instability.
Our study provides the first evidence that β-endorphin contributes to the acceleration of the progression and instability of atheromatous plaques.
Thus, μ-opioid receptor antagonists may be useful for the prevention and treatment of atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Okano, Taisuke& Sato, Kengo& Shirai, Remina& Seki, Tomomi& Shibata, Koichiro& Yamashita, Tomoyuki…[et al.]. 2020. β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques. International Journal of Endocrinology،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170281
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Okano, Taisuke…[et al.]. β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques. International Journal of Endocrinology No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1170281
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Okano, Taisuke& Sato, Kengo& Shirai, Remina& Seki, Tomomi& Shibata, Koichiro& Yamashita, Tomoyuki…[et al.]. β-Endorphin Mediates the Development and Instability of Atherosclerotic Plaques. International Journal of Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1170281
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1170281
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر