VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma’anshan Birth Cohort (MABC) Study
المؤلفون المشاركون
Tao, Fang-Biao
Zhu, Beibei
Huang, Kun
Yan, Shuangqin
Hao, Jiahu
Zhu, Peng
Chen, Yao
Ye, Aoxing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
This study investigated the associations among early pregnancy vitamin D concentrations, seasonality, and vitamin D metabolic gene variants and how these variables related alone and in interaction with the risk of gestational diabetes mellitus (GDM).
Methods.
Research participants were women from the Ma’anshan birth cohort study in China.
The overall study included 3110 women to explore the association between early pregnancy vitamin D concentrations and the risk of GDM.
In the current analysis, a nested case-control study of 274 GDM cases and 380 controls was conducted to investigate seven vitamin D metabolic gene variants and the risk of GDM.
Vitamin D concentrations were measured by radioimmunoassay.
Genotypes were determined by improved multiple ligase detection reaction.
Interactions between genetic variants and vitamin D as predictors of the risk of GDM were evaluated by a pair-wise analysis under a multiplicative interaction model.
Results.
Vitamin D concentrations were not significantly associated with the risk of GDM (OR=0.79, 95% CI=0.55-1.13) after adjusting for seasonality.
Fall-winter conceptions had a 37% decreased risk of GDM compared with spring-summer conceptions (OR=0.63, 95% CI=0.49-0.81), independent of vitamin D concentrations.
Two VDR gene variants rs1544410 (OR=2.03, 95% CI=1.17-3.51 for CT versus CC) and rs731236 (OR=2.42, 95% CI=1.29-4.55 for GA versus AA) were significantly associated with the risk of GDM.
No interactions among genetic variants and vitamin D concentrations were detected.
Conclusion.
Early pregnancy vitamin D insufficiency or deficiency was not significantly associated with the risk of GDM.
The results of this study emphasize the importance of genetic variants in VDR and conception season as factors that affect the risk of GDM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Beibei& Huang, Kun& Yan, Shuangqin& Hao, Jiahu& Zhu, Peng& Chen, Yao…[et al.]. 2019. VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma’anshan Birth Cohort (MABC) Study. Journal of Diabetes Research،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Beibei…[et al.]. VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma’anshan Birth Cohort (MABC) Study. Journal of Diabetes Research No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1173277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Beibei& Huang, Kun& Yan, Shuangqin& Hao, Jiahu& Zhu, Peng& Chen, Yao…[et al.]. VDR Variants rather than Early Pregnancy Vitamin D Concentrations Are Associated with the Risk of Gestational Diabetes: The Ma’anshan Birth Cohort (MABC) Study. Journal of Diabetes Research. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1173277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر