Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients
المؤلفون المشاركون
Duarte, Raquel
Naicker, Saraladevi
Manga, Pravin
Hassan, Muzamil Olamide
Naidoo, Sagren
Vachiat, Ahmed
Grinter, Sacha
Dix-Peek, Thérèse
Dickens, Caroline
المصدر
International Journal of Nephrology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Transforming growth factor-β (TGF-β) may inhibit the development of atherosclerosis.
We evaluated serum levels of TGF-β isoforms concurrently with serum levels of endotoxin and various inflammatory markers.
In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atherosclerosis in South African CKD patients.
Methods.
We studied 120 CKD patients and 40 healthy controls.
Serum TGF-β1, TGF-β2, TGF-β3, endotoxin, and inflammatory markers were measured.
Functional polymorphisms in the TGF-β1 genes were genotyped using a polymerase chain reaction-sequence specific primer method and carotid intima media thickness (CIMT) was assessed by B-mode ultrasonography.
Results.
TGF-β isoforms levels were significantly lower in the patients with atherosclerosis compared to patients without atherosclerosis (p<0.001).
Overall, TGF-β isoforms had inverse relationships with CIMT.
TGF-β1 and TGF-β2 levels were significantly lower in patients with carotid plaque compared to those without carotid plaque [TGF-β1: 31.9 (17.2 – 42.2) versus 45.9 (35.4 – 58.1) ng/ml, p=0.016; and TGF-β2: 1.46 (1.30 – 1.57) versus 1.70 (1.50 – 1.87) ng/ml, p=0.013].
In multiple logistic regression, age, TGF-β2, and TGF-β3 were the only independent predictors of subclinical atherosclerosis in CKD patients [age: odds ratio (OR), 1.054; 95% confidence interval (CI): 1.003 – 1.109, p=0.039; TGF-β2: OR, 0.996; 95% CI: 0.994–0.999, p=0.018; TGF-β3: OR, 0.992; 95% CI: 0.985–0.999, p=0.029).
TGF-β1 genotypes did not influence serum levels of TGF-β1 and no association was found between the TGF-β1 gene polymorphisms and atherosclerosis risk.
Conclusion.
TGF-β isoforms seem to offer protection against the development of atherosclerosis among South African CKD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hassan, Muzamil Olamide& Duarte, Raquel& Dix-Peek, Thérèse& Dickens, Caroline& Naidoo, Sagren& Vachiat, Ahmed…[et al.]. 2018. Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. International Journal of Nephrology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1173676
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hassan, Muzamil Olamide…[et al.]. Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. International Journal of Nephrology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1173676
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hassan, Muzamil Olamide& Duarte, Raquel& Dix-Peek, Thérèse& Dickens, Caroline& Naidoo, Sagren& Vachiat, Ahmed…[et al.]. Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. International Journal of Nephrology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1173676
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1173676
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر