The Effect of Lymph Nodes’ Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer

المؤلفون المشاركون

Chbani, Laila
El Otmani, Ihsane
El Agy, Fatima
El Abkari, Mohammed
Hassani, Karim Ibn Majdoub
Mazaz, Khalid
Benjelloun, El Bachir
Bouhafa, Touria
Ibrahimi, Sidi Adil
Ait Taleb, K.
Benbrahim, Zineb

المصدر

International Journal of Surgical Oncology

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-01-06

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Prognosis for patients with locally advanced rectal cancer remains controversial.

The purpose of this study was to elucidate possible association between therapeutic effect on lymph nodes (LNs) and patient prognosis.

Overall, 149 patients with rectal cancer received preoperative radiotherapy in concomitance with chemotherapy or exclusive radiotherapy before rectal excision.

Microscopic examination of formalin-fixed lymph nodes was assessed for therapeutic effect.

The establishment of groups combined reaction tissue types of fibrosis, colloid, and necrosis after neoadjuvant treatment was assigned.

The average age was 56.38 years, ranged between 22 and 88 years, 53% were female, and 47% were men, with a sex ratio of 1 : 12.

In the present study, we noticed that after a median follow-up time of 40.67 months (0–83; SD: 21.1), overall survival was statistically significant depending on age groups.

Kaplan–Meier analysis showed significant differences in the rate of patients with an age under 65 years (70.64%) versus those with an age over 85 years (36.5%) (p<0.001).

Also, the OS was statistically significant depending on therapeutic effect groups composed of 0TE (No Therapeutic effect), C+ (presence of only colloidal effect), F+ (presence of only fibrosis tissue), and ME+ (mixture of 2 or 3 types of therapeutic effect) group.

Indeed, we observed a significantly higher OS rate in the ME + group (86%) compared with the OS rate of LNs group with no therapeutic effect (57%) (p=0.028).

Additionally, there was a significant association between the presence of fibrosis on LNs and an extended delay of more than 8 weeks to neoadjuvant treatment completion and surgery.

Our study indicates that the best patient prognosis could be predicted based on tumor presenting a best pathologic effect on lymph nodes, and that delaying surgery for more than 8 weeks to neoadjuvant treatment completion improves therapeutic response on LNs.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

El Otmani, Ihsane& El Agy, Fatima& El Abkari, Mohammed& Hassani, Karim Ibn Majdoub& Mazaz, Khalid& Benjelloun, El Bachir…[et al.]. 2020. The Effect of Lymph Nodes’ Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer. International Journal of Surgical Oncology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1174173

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

El Otmani, Ihsane…[et al.]. The Effect of Lymph Nodes’ Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer. International Journal of Surgical Oncology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1174173

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

El Otmani, Ihsane& El Agy, Fatima& El Abkari, Mohammed& Hassani, Karim Ibn Majdoub& Mazaz, Khalid& Benjelloun, El Bachir…[et al.]. The Effect of Lymph Nodes’ Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer. International Journal of Surgical Oncology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1174173

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1174173