Epithelial Cell Adhesion Molecule in Primary Sjögren’s Syndrome Patients: Characterization and Evaluation of a Potential Biomarker
المؤلفون المشاركون
Zhu, Ping
Zhang, Kui
Zhou, Yaxin
Cheng, Xiaojing
Fu, Xianghui
Du, Wanglei
Feng, Yuan
Jia, Junfeng
Yang, Xichao
Xiao, Guangzhi
Zheng, Zhaohui
Wu, Zhenbiao
المصدر
Journal of Immunology Research
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To determine the subcellular localization of epithelial cell adhesion molecule (EpCAM) in labial salivary gland (LSG) and evaluate the diagnostic use of the extracellular domain of EpCAM (EpEX) and intracellular domain (EpICD) for primary Sjögren’s syndrome (pSS).
Methods.
Immunohistochemical (IHC) analysis was conducted using EpEX and EpICD domain-specific antibodies on labial salivary gland biopsy (LSGB) from participants.
Chi-square or Fisher’s exact analysis, Mann–Whitney U-test, and Kruskal-Wallis test compared differences among groups.
Independent risk factors of pSS were determined by multiple logistic regression analysis.
Receiver-operator characteristic curves (ROC) were carried out to estimate the diagnostic value.
Results.
Compared to non-SS controls, loss of membranous EpEX and EpICD expression was observed in LSGB of pSS patients, which occurred in parallel with increased accumulation of cytoplastic and nuclear EpICD.
The subcellular EpEX/EpICD expressions were associated with various features of pSS patients, especially histopathological grade of LSGB.
Furthermore, high IHC scores of membranous EpEX were independent risk factors for pSS, even for the pSS patients at early stage.
The IHC scores of subcellular EpEX/EpICD were of great diagnostic value for pSS with high sensitivity (70-80%) and specificity (85-95%).
Conclusion.
This study first found the aberrant expression pattern of EpCAM in LSG of pSS patients.
The IHC scores of subcellular EpEX/EpICD were demonstrated to have the potential to act as diagnostic biomarkers for pSS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Kui& Zhou, Yaxin& Cheng, Xiaojing& Fu, Xianghui& Du, Wanglei& Feng, Yuan…[et al.]. 2019. Epithelial Cell Adhesion Molecule in Primary Sjögren’s Syndrome Patients: Characterization and Evaluation of a Potential Biomarker. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176040
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Kui…[et al.]. Epithelial Cell Adhesion Molecule in Primary Sjögren’s Syndrome Patients: Characterization and Evaluation of a Potential Biomarker. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1176040
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Kui& Zhou, Yaxin& Cheng, Xiaojing& Fu, Xianghui& Du, Wanglei& Feng, Yuan…[et al.]. Epithelial Cell Adhesion Molecule in Primary Sjögren’s Syndrome Patients: Characterization and Evaluation of a Potential Biomarker. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1176040
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1176040
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر