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The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women
المؤلفون المشاركون
Appiah, Duke
Baumgartner, Richard N.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-25
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
We investigated the risk of death in relation to the apolipoprotein ε4 allele and evaluated how it interacts with education in 504 elderly adults (mean age 73 years, 65.3% women) who were enrolled in 1993 into the New Mexico Aging Process Study.
During 9 years of follow-up, apolipoprotein ε2 appeared to be associated with a lower risk for all-cause mortality (hazard ratio (HR) = 0.73, 95% confidence interval (CI): 0.30–1.71) compared to apolipoprotein ε3 carriers in models adjusted for age, sociodemographic variables, medical conditions, adiposity, and lifestyle factors.
The apolipoprotein ε4 allele conferred almost a threefold elevated risk of mortality (HR = 2.76, CI: 1.42–5.37).
An interaction between education and apolipoprotein e4 (p=0.027) was observed with the HR of mortality among e4 carriers compared to noncarriers being 1.59 (0.64–3.96) for those with ≥college education; 6.66 (1.90–23.4) for those with some college or trade; and 14.1 (3.03–65.6) for participants with ≤high school education.
No significant interaction was identified between apolipoprotein E genotype and cognitive function for mortality risk.
These findings suggest that genetic (apolipoprotein ε4) and environmental (education) factors act interactively to influences survival in the elderly with higher education attenuating the adverse effect of apolipoprotein ε4 on mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Appiah, Duke& Baumgartner, Richard N.. 2018. The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women. Journal of Aging Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1180755
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Appiah, Duke& Baumgartner, Richard N.. The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women. Journal of Aging Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1180755
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Appiah, Duke& Baumgartner, Richard N.. The Influence of Education and Apolipoprotein ε4 on Mortality in Community-Dwelling Elderly Men and Women. Journal of Aging Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1180755
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1180755
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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