The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers
المؤلفون المشاركون
Kaewkangsadan, Viriya
Verma, Chandan
Eremin, Jennifer M.
Cowley, Gerard
Ilyas, Mohammed
Eremin, Oleg
Satthaporn, Sukchai
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-23
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
The tumour microenvironment consists of malignant cells, stroma, and immune cells.
The role of adaptive immunity in inducing a pathological complete response (pCR) in breast cancer with neoadjuvant chemotherapy (NAC) is well studied.
The contribution of innate immunity, however, is poorly documented.
Breast tumours and axillary lymph nodes (ALNs) from 33 women with large and locally advanced breast cancers (LLABCs) undergoing NAC were immunohistochemically assessed for tumour-infiltrating macrophages (TIMs: M1 and M2), neutrophils (TINs), and dendritic cells (TIDCs) using labelled antibodies and semiquantitative methods.
Patients’ blood neutrophils (n=108), DCs (mDC1 and pDC), and their costimulatory molecules (n=30) were also studied.
Pathological results were classified as pCR, good (GPR) or poor (PRR).
In breast and metastatic ALNs, high levels of CD163+ TIMs were significantly associated with a pCR.
In blood, high levels of neutrophils were significantly associated with pCR in metastatic ALNs, whilst the % of mDC1 and pDC and expression of HLA-DR, mDC1 CD40, and CD83 were significantly reduced.
NAC significantly reduced tumour DCs but increased blood DCs.
PPRs to NAC had significantly reduced HLA-DR, CD40, and CD86 expression.
Our study demonstrated novel findings documenting the differential but important contributions of innate immunity to pCRs in patients with LLABCs undergoing NAC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaewkangsadan, Viriya& Verma, Chandan& Eremin, Jennifer M.& Cowley, Gerard& Ilyas, Mohammed& Satthaporn, Sukchai…[et al.]. 2017. The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1181544
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaewkangsadan, Viriya…[et al.]. The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers. Journal of Immunology Research No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1181544
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaewkangsadan, Viriya& Verma, Chandan& Eremin, Jennifer M.& Cowley, Gerard& Ilyas, Mohammed& Satthaporn, Sukchai…[et al.]. The Differential Contribution of the Innate Immune System to a Good Pathological Response in the Breast and Axillary Lymph Nodes Induced by Neoadjuvant Chemotherapy in Women with Large and Locally Advanced Breast Cancers. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1181544
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181544
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر