Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis
المؤلفون المشاركون
Hawkins, Charlene
Shaginurova, Guzel
Shelton, D. Auriel
Herazo-Maya, Jose D.
Oswald-Richter, Kyra A.
Rotsinger, Joseph E.
Young, Anjuli
Celada, Lindsay J.
Kaminski, Naftali
Sevin, Carla
Drake, Wonder P.
المصدر
Journal of Immunology Research
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Investigation of the Th1 immune response in sarcoidosis CD4+ T cells has revealed reduced proliferative capacity and cytokine expression upon TCR stimulation.
In other disease models, such cellular dysfunction has been associated with a step-wise, progressive loss of T cell function that results from chronic antigenic stimulation.
T cell exhaustion is defined by decreased cytokine production upon TCR activation, decreased proliferation, increased expression of inhibitory cell surface receptors, and increased susceptibility to apoptosis.
We characterized sarcoidosis CD4+ T cell immune function in systemic and local environments among subjects undergoing disease progression compared to those experiencing disease resolution.
Spontaneous and TCR-stimulated Th1 cytokine expression and proliferation assays were performed in 53 sarcoidosis subjects and 30 healthy controls.
PD-1 expression and apoptosis were assessed by flow cytometry.
Compared to healthy controls, sarcoidosis CD4+ T cells demonstrated reductions in Th1 cytokine expression, proliferative capacity (p<0.05), enhanced apoptosis (p<0.01), and increased PD-1 expression (p<0.001).
BAL-derived CD4+ T cells also demonstrated multiple facets of T cell exhaustion (p<0.05).
Reversal of CD4+ T cell exhaustion was observed in subjects undergoing spontaneous resolution (p<0.05).
Sarcoidosis CD4+ T cells exhibit loss of cellular function during progressive disease that follows the archetype of T cell exhaustion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hawkins, Charlene& Shaginurova, Guzel& Shelton, D. Auriel& Herazo-Maya, Jose D.& Oswald-Richter, Kyra A.& Rotsinger, Joseph E.…[et al.]. 2017. Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1181736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hawkins, Charlene…[et al.]. Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. Journal of Immunology Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1181736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hawkins, Charlene& Shaginurova, Guzel& Shelton, D. Auriel& Herazo-Maya, Jose D.& Oswald-Richter, Kyra A.& Rotsinger, Joseph E.…[et al.]. Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1181736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1181736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر