From Humoral Theory to Performant Risk Stratification in Kidney Transplantation

المؤلفون المشاركون

Lefaucheur, C.
Viglietti, D.
Mangiola, M.
Loupy, A.
Zeevi, A.

المصدر

Journal of Immunology Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-01-02

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأحياء

الملخص EN

The purpose of the present review is to describe how we improve the model for risk stratification of transplant outcomes in kidney transplantation by incorporating the novel insights of donor-specific anti-HLA antibody (DSA) characteristics.

The detection of anti-HLA DSA is widely used for the assessment of pre- and posttransplant risks of rejection and allograft loss; however, not all anti-HLA DSA carry the same risk for transplant outcomes.

These antibodies have been shown to cause a wide spectrum of effects on allografts, ranging from the absence of injury to indolent or full-blown acute antibody-mediated rejection.

Consequently, the presence of circulating anti-HLA DSA does not provide a sufficient level of accuracy for the risk stratification of allograft outcomes.

Enhancing the predictive performance of anti-HLA DSA is currently one of the most pressing unmet needs for facilitating individualized treatment choices that may improve outcomes.

Recent advancements in the assessment of anti-HLA DSA properties, including their strength, complement-binding capacity, and IgG subclass composition, significantly improved the risk stratification model to predict allograft injury and failure.

Although risk stratification based on anti-HLA DSA properties appears promising, further specific studies that address immunological risk stratification in large and unselected populations are required to define the benefits and cost-effectiveness of such comprehensive assessment prior to clinical implementation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lefaucheur, C.& Viglietti, D.& Mangiola, M.& Loupy, A.& Zeevi, A.. 2017. From Humoral Theory to Performant Risk Stratification in Kidney Transplantation. Journal of Immunology Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181910

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lefaucheur, C.…[et al.]. From Humoral Theory to Performant Risk Stratification in Kidney Transplantation. Journal of Immunology Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1181910

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lefaucheur, C.& Viglietti, D.& Mangiola, M.& Loupy, A.& Zeevi, A.. From Humoral Theory to Performant Risk Stratification in Kidney Transplantation. Journal of Immunology Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1181910

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1181910