Synthesis and Antifungal Activity of β-Hydroxysulfides of 1,3-Dioxepane Series

الملخص EN

Synthesis of β-hydroxysulfides of 1,3-dioxepane series and their further functionalization were performed.

Chiral β-hydroxysulfides were separated into enantiomers using enzymatic acylation by lipase PS.

Study of antifungal activity of the obtained compounds showed that some enantiomerically pure 6-arylthio-1,3-dioxepan-5-ols represent promising antifungal drug candidates.