Association between 1,5-Anhydroglucitol and Acute C Peptide Response to Arginine among Patients with Type 2 Diabetes

الملخص EN

Objective.

The aim of this study was to explore the association of 1,5-anhydroglucitol with acute C peptide response (ACPR) to arginine among patients with type 2 diabetes.

Methods.

Patients with type 2 diabetes were enrolled from the Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital.

ACPR was assessed using arginine stimulation test.

Decreased β-cell function was defined as ACPR<2.1.

Multivariable logistic regression models were used to demonstrate the association between 1,5-anhydroglucitol and decreased β-cell function.

Results.

Finally, 623 patients with type 2 diabetes were enrolled into the analysis.

Multivariable-adjusted odds ratios for decreased β-cell function across quartiles of 1,5-anhydroglucitol were 1.00, 0.47 (95% confidence interval (CI) 0.23-0.99), 0.41 (95% CI 0.20-0.84), and 0.27 (95% CI 0.13-0.57) (Ptrend=0.042), respectively.

When 1,5-anhydroglucitol was considered as a continuous variable after logarithm, the corresponding odds ratio was 0.40 (95% CI 0.23-0.71).

Conclusions.

We demonstrated a dose-response linear association between 1,5-anhydroglucitol and ACPR.

1,5-Anhydroglucitol was likely to be associated with β-cell function.

Further analysis with large sample size and prospective study design is warranted to validate our findings.