Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs
المؤلفون المشاركون
Martins, Joilson O.
Tessaro, Fernando H. G.
Nunes, Fernanda P. B.
Ferreira, Sabrina S.
Casagrande, Felipe Beccaria
Romera, Lavínia Maria Dal’Mas
dos Santos, Suelen Silvana
de Souza, Paula Regina Knox
Almeida, Sandro Rogério
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients.
We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis Paracoccidioides brasiliensis (Pb) model.
Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments.
After 55 days, infected diabetic mice exhibited fewer leukocytes in both peritoneal lavage fluid (PeLF) and bronchoalveolar lavage fluid and reduced secretion of interleukin- (IL-) 6 in lungs.
In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups.
Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals.
The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Casagrande, Felipe Beccaria& Ferreira, Sabrina S.& Nunes, Fernanda P. B.& Romera, Lavínia Maria Dal’Mas& dos Santos, Suelen Silvana& Tessaro, Fernando H. G.…[et al.]. 2018. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Casagrande, Felipe Beccaria…[et al.]. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. Journal of Diabetes Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1183761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Casagrande, Felipe Beccaria& Ferreira, Sabrina S.& Nunes, Fernanda P. B.& Romera, Lavínia Maria Dal’Mas& dos Santos, Suelen Silvana& Tessaro, Fernando H. G.…[et al.]. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1183761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر