The HOMA-IR Performance to Identify New Diabetes Cases by Degree of Urbanization and Altitude in Peru: The CRONICAS Cohort Study
المؤلفون المشاركون
Bernabe-Ortiz, Antonio
Smeeth, Liam
Checkley, William
Miranda, J. Jaime
Study Group, CRONICAS Cohort
Carrillo-Larco, Rodrigo M.
Gilman, Robert H.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
Prognostic thresholds to identify new type 2 diabetes mellitus (T2DM) cases using the HOMA-IR have not been defined.
We studied the HOMA-IR performance to identify incident T2DM cases and to assess if the thresholds varied according to urbanization and altitude in Peru.
Methods.
Longitudinal analysis.
The outcome was incident T2DM cases: self-report diagnosis and fasting glucose.
The exposure was the HOMA-IR.
Receiver operating characteristic (ROC) curves were plotted, and the area under the ROC curve (AUC) was estimated with 95% confidence intervals (95% CIs).
Results are presented overall and stratified by study site (Lima, Tumbes, urban Puno, and rural Puno), rurality (urban, semiurban, and rural), and altitude (low and high).
Results.
A total of 3120 participants (mean age: 55.6 years, 51.2% females) contributed data to this analysis.
The median baseline HOMA-IR was 1.7 (IQR 1.0–2.9), with median values ranging from 1.1 in rural Puno to 2.0 in Lima and Tumbes (p<0.001).
Overall for incident T2DM, the AUC was 0.69 (95% CI: 0.64–0.74) with an empirical threshold of 2.8 yielding a positive likelihood ratio of 2.30 and a negative one of 0.61; the positive and negative predictive values were 14.6% and 95.7%, respectively.
The empirical thresholds varied within the variables of interest, for example, from 0.9 in urban Puno to 2.9 in Lima.
Conclusions.
Using the HOMA-IR to identify incident T2DM cases seems to yield moderate accuracy.
The HOMA-IR could help improve identifying people at high risk of T2DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carrillo-Larco, Rodrigo M.& Miranda, J. Jaime& Gilman, Robert H.& Checkley, William& Smeeth, Liam& Bernabe-Ortiz, Antonio…[et al.]. 2018. The HOMA-IR Performance to Identify New Diabetes Cases by Degree of Urbanization and Altitude in Peru: The CRONICAS Cohort Study. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carrillo-Larco, Rodrigo M.…[et al.]. The HOMA-IR Performance to Identify New Diabetes Cases by Degree of Urbanization and Altitude in Peru: The CRONICAS Cohort Study. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carrillo-Larco, Rodrigo M.& Miranda, J. Jaime& Gilman, Robert H.& Checkley, William& Smeeth, Liam& Bernabe-Ortiz, Antonio…[et al.]. The HOMA-IR Performance to Identify New Diabetes Cases by Degree of Urbanization and Altitude in Peru: The CRONICAS Cohort Study. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1183857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر