There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients

المؤلفون المشاركون

Dalboni, Maria Aparecida
Coutinho, Mariana Nogueira
Mouro, Margaret Gori
Higa, Elisa Mieko Suemitsu
Costa-Hong, Valéria
Bortolotto, Luiz Aparecido
Figueiredo, Rejane Augusta de Oliveira
Canziani, Maria Eugênia Fernandes
Carvalho, A. B.

المصدر

Journal of Diabetes Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-11-25

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Background.

Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality.

Several studies have separately analyzed endothelial function in these populations.

However, data of patients with both CKD and DM are scarce.

The aim of this study was to evaluate whether the presence of DM has any additional effect on the endothelial dysfunction of CKD patients.

Methods.

We measured endothelial progenitor cells (EPCs), stromal-derived factor 1 alpha (SDF-1α), serum and urinary nitric oxide (NO), flow-mediated dilation (FMD), and pulse wave velocity (PWV) in 37 CKD patients with DM (CKD-DM group) and in 37 without DM (CKD group).

Results.

CKD-DM group had a higher prevalence of obesity (P<0.01), previous myocardial infarction (P=0.02), myocardial revascularization (P=0.04), and a trend for more peripheral artery disease (P=0.07).

Additionally, CKD-DM group had higher EPC (P=0.001) and PWV (P<0.001) values.

On the other hand, no difference in SDF-1α and serum or urinary NO and FMD was observed between the groups.

Conclusions.

Endothelial dysfunction is frequent in CKD patients, and an additive effect of diabetes cannot be implicated, suggesting the predominant role of uremia in this condition.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Coutinho, Mariana Nogueira& Carvalho, A. B.& Dalboni, Maria Aparecida& Mouro, Margaret Gori& Higa, Elisa Mieko Suemitsu& Costa-Hong, Valéria…[et al.]. 2018. There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients. Journal of Diabetes Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183911

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Coutinho, Mariana Nogueira…[et al.]. There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients. Journal of Diabetes Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1183911

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Coutinho, Mariana Nogueira& Carvalho, A. B.& Dalboni, Maria Aparecida& Mouro, Margaret Gori& Higa, Elisa Mieko Suemitsu& Costa-Hong, Valéria…[et al.]. There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients. Journal of Diabetes Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1183911

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1183911