Tubal Origin of “Ovarian” Low-Grade Serous Carcinoma: A Gene Expression Profile Study
المؤلفون المشاركون
Kong, Beihua
Wang, Yiying
Hong, Shuhui
Mu, Jingyi
Wang, Yue
Lea, Jayanthi
Zheng, Wenxin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Ovarian low-grade serous carcinomas are thought to evolve in a stepwise fashion from ovarian epithelial inclusions, serous cystadenomas, and serous borderline tumors.
Our previous study with clinicopathological approach showed that the majority ovarian epithelial inclusions are derived from the fallopian tubal epithelia rather than from ovarian surface epithelia.
This study was designed to gain further insight into the cellular origin of ovarian low-grade serous carcinomas by differential gene expression profiling studies.
Methods.
Gene expression profiles were studied in 43 samples including 11 ovarian low-grade serous carcinomas, 7 serous borderline tumors, 6 serous cystadenomas, 6 ovarian epithelial inclusions, 7 fallopian tubal epithelia, and 6 ovarian surface epithelia.
Comprehensive analyses with hierarchical clustering, Rank-sum analysis and Pearson correlation tests were performed.
Final validation was done on selected genes and corresponding proteins.
Results.
The gene expression profiles distinguished ovarian low-grade serous carcinomas from ovarian surface epithelia, but not from fallopian tubal epithelia cells.
Hierarchical clustering analysis showed ovarian serous tumors and ovarian epithelial inclusions were clustered closely in a branch, but separated from ovarian surface epithelia.
The results were further validated by selected proteins of OVGP1, WT-1, and FOM3, which were highly expressed in the samples of the fallopian tube, ovarian epithelial inclusions, and ovarian serous tumors, but not in ovarian surface epithelia.
The reverse was true for the protein expression patterns of ARX and FNC1.
Conclusions.
This study provides evidence in a molecular level that ovarian low-grade serous carcinomas likely originate from the fallopian tube rather than from ovarian surface epithelia.
Similar gene expression profiles among fallopian tube, ovarian epithelial inclusions, and serous tumors further support that ovarian low-grade serous carcinomas develop in a stepwise fashion.
Such findings may have a significant implication for “ovarian” cancer-prevention strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yiying& Hong, Shuhui& Mu, Jingyi& Wang, Yue& Lea, Jayanthi& Kong, Beihua…[et al.]. 2019. Tubal Origin of “Ovarian” Low-Grade Serous Carcinoma: A Gene Expression Profile Study. Journal of Oncology،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184615
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yiying…[et al.]. Tubal Origin of “Ovarian” Low-Grade Serous Carcinoma: A Gene Expression Profile Study. Journal of Oncology No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1184615
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yiying& Hong, Shuhui& Mu, Jingyi& Wang, Yue& Lea, Jayanthi& Kong, Beihua…[et al.]. Tubal Origin of “Ovarian” Low-Grade Serous Carcinoma: A Gene Expression Profile Study. Journal of Oncology. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1184615
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1184615
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر