Nε-Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1Rac1 Pathway
المؤلفون المشاركون
Yan, Jinchuan
Wang, Zhongqun
Bao, Zhengyang
Zhang, Lili
Li, Lihua
Pang, Qiwen
Sun, Zhen
Geng, Yue
Jing, Lele
Shao, Chen
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Macrophage-derived foam cells play a central role in atherosclerosis, and their ultimate fate includes apoptosis, promotion of vascular inflammation, or migration to other tissues.
Nε-Carboxymethyl-lysine (CML), the key active component of advanced glycation end products, induced foam cell formation and apoptosis.
Previous studies have shown that the Vav1/Rac1 pathway affects the macrophage cytoskeleton and cell migration, but its role in the pathogenesis of diabetic atherosclerosis is unknown.
Methods and Results.
In this study, we used anterior tibiofibular vascular samples from diabetic foot amputation patients and accident amputation patients, and histological and cytological tests were performed using a diabetic ApoE-/- mouse model and primary peritoneal macrophages, respectively.
The results showed that the atherosclerotic plaques of diabetic foot amputation patients and diabetic ApoE-/- mice were larger than those of the control group.
Inhibition of the Vav1/Rac1 pathway reduced vascular plaques and promoted the migration of macrophages to lymph nodes.
Transwell and wound healing assays showed that the migratory ability of macrophage-derived foam cells was inhibited by CML.
Cytoskeletal staining showed that advanced glycation end products inhibited the formation of lamellipodia in foam cells, and inhibition of the Vav1/Rac1 pathway restored the formation of lamellipodia.
Conclusion.
CML inhibits the migration of foam cells from blood vessels via the Vav1/Rac1 pathway, and this process affects the formation of lamellipodia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bao, Zhengyang& Zhang, Lili& Li, Lihua& Yan, Jinchuan& Pang, Qiwen& Sun, Zhen…[et al.]. 2020. Nε-Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1Rac1 Pathway. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1186946
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bao, Zhengyang…[et al.]. Nε-Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1Rac1 Pathway. Journal of Immunology Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1186946
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bao, Zhengyang& Zhang, Lili& Li, Lihua& Yan, Jinchuan& Pang, Qiwen& Sun, Zhen…[et al.]. Nε-Carboxymethyl-Lysine Negatively Regulates Foam Cell Migration via the Vav1Rac1 Pathway. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1186946
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1186946
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر