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Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALBc Mice
المؤلفون المشاركون
He, Xiaoyan
Shi, Bin
Zhang, Teng
Ma, Long
Ma, Rui
Duan, Fangfang
Su, Danhua
Yang, Jiezuan
Sun, Suhong
Yao, Xinsheng
المصدر
Journal of Immunology Research
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-24
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
To study the homogeneity and heterogeneity of CD4+CD25+ T cells receptor β-chain complementarity determining region 3 (TCR β CDR3) repertoires in breast tumor tissues, lung metastatic tissues, and spleens from 4T1 tumor-bearing BALB/c mice.
We used high-throughput sequencing to analyze the characteristics and changes of CD4+CD25+ TCR β CDR3 repertoires among tumor tissues, lung metastatic tissues, and spleens.
The diversity of the CD4+CD25+ TCR β CDR3 repertoires in breast tumor tissue was similar to that of lung metastatic tissues and less pronounced than that of spleen tissues.
Breast tumor tissues and lung metastatic tissues had a greater number of high-frequency CDR3 sequences and intermediate-frequency CDR3 sequences than those of spleens.
The proportion of unique productive CDR3 sequences in breast tumor tissues and lung metastatic tissues was significantly greater than that in the spleens.
The diversity and frequency of the CDR3 repertoires remained homogeneous in breast tumors and lung metastatic tissues and showed great heterogeneity in the spleens, which suggested that the breast tissues and lung metastatic tissues have characteristics of CD4+CD25+ T cells that relate to the tumor microenvironment.
However, the number and characteristics of overlapping CDR3 sequences suggested that there were some different CD4+CD25+ T cells in tumors and in the circulatory immune system.
The study may be used to further explore the characteristics of the CDR3 repertoires and determine the source of the CD4+CD25+ T cells in the breast cancer microenvironment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Teng& Duan, Fangfang& Su, Danhua& Ma, Long& Yang, Jiezuan& Shi, Bin…[et al.]. 2020. Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALBc Mice. Journal of Immunology Research،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1187119
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Teng…[et al.]. Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALBc Mice. Journal of Immunology Research No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1187119
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Teng& Duan, Fangfang& Su, Danhua& Ma, Long& Yang, Jiezuan& Shi, Bin…[et al.]. Analysis of the Heterogeneity of CD4+CD25+ T Cell TCR β CDR3 Repertoires in Breast Tumor Tissues, Lung Metastatic Tissues, and Spleens from 4T1 Tumor-Bearing BALBc Mice. Journal of Immunology Research. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1187119
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1187119
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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