Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation
المؤلفون المشاركون
Baptista, Filipa I.
Ambrósio, António F.
Aveleira, Célia A.
Castilho, Áurea F.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology.
Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β).
However, how high glucose and IL-1β affect the different retinal cell types remains to be clarified.
In retinal neural cell cultures, we found that IL-1β and IL-1RI are present in microglia, macroglia, and neurons.
Exposure of retinal neural cell cultures to high glucose upregulated both mRNA and protein levels of IL-1β.
High glucose decreased microglial and macroglial cell proliferation, whereas IL-1β increased their proliferation.
Interestingly, under high glucose condition, although the number of microglial cells decreased, they showed a less ramified morphology, suggesting a more activated state, as supported by the upregulation of the levels of ED-1, a marker of microglia activation.
In conclusion, IL-1β might play a key role in diabetic retinopathy, affecting microglial and macroglial cells and ultimately contributing to neural changes observed in diabetic patients.
Particularly, since IL-1β has an important role in retinal microglia activation and proliferation under diabetes, limiting IL-1β-triggered inflammatory processes may provide a new therapeutic strategy to prevent the progression of diabetic retinopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baptista, Filipa I.& Aveleira, Célia A.& Castilho, Áurea F.& Ambrósio, António F.. 2017. Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baptista, Filipa I.…[et al.]. Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation. Mediators of Inflammation No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1188324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baptista, Filipa I.& Aveleira, Célia A.& Castilho, Áurea F.& Ambrósio, António F.. Elevated Glucose and Interleukin-1β Differentially Affect Retinal Microglial Cell Proliferation. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1188324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر