An Individual Patient Data Meta-Analysis with Colombian Studies on the Effect of Dark Chocolate Consumption on Cardiovascular Risk Parameters
المؤلفون المشاركون
Alvarez, Leidy
Contreras, Javier
Giraldo, Mónica
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
It is postulated that cocoa solids possess cardioprotective capacity by various mechanisms.
In the different cocoa studies evaluating cardiovascular disease, there are no conclusive data on the role it plays in controlling the lipid profile and anthropometric variables, perhaps because the concentration of cocoa, the geographical origin of the population, and the different concentrations supplied lead to a high heterogeneity of results.
This study aims to estimate the effect of consuming cocoa-rich chocolate compared to placebo on the lipid profile and anthropometric variables based on data from three clinical trials conducted in Colombia.
Methods.
Meta-analysis of individual data from three randomized clinical trials conducted in Colombia.
The entire population of the primary studies was included, which was reassigned into intervention groups if they consumed 50 grams of 70% concentrated cocoa or placebo, which was considered to be cocoa-free or with a concentration less than 50 grams.
The variables at the beginning of the study were analyzed with medians, interquartile ranges, means, and deviations according to whether they met the normality assumption.
Multiple imputations were used to manage missing data and were analyzed using the two approaches proposed for this type of study, that of one and two stages.
In the two-stage approach, the data were weighted on a conventional Forrest plot, while in the one-stage approach, linear regressions with mixed models were applied.
This study is governed by the regulations described in the 2013 Declaration of Helsinki and by article 11 of Resolution 8430 of 1993, which classifies it as a risk-free study.
Results.
A total of 275 participants were included, who consumed cocoa or placebo for 81 days on average; 52.7% were female and few smoked at the time of the intervention (31/275).
Physical activity performed in number of hours per week was comparable between the intervention groups.
When evaluating total cholesterol, low-density cholesterol (LDL), high-density cholesterol (HDL), triglycerides, abdominal circumference, and final body mass index with both the one-stage and two-stage approaches, there were no significant differences between the two groups.
Conclusions.
According to the results obtained in the meta-analysis, the consumption of cocoa in the Colombian population does not seem to significantly modify variables such as lipid profile, abdominal circumference, and body mass index.
This conclusion according to the quality of the evidence has a weak recommendation and a low-to-moderate certainty.
However, the analysis through the two proposed approaches yielded similar results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alvarez, Leidy& Contreras, Javier& Giraldo, Mónica. 2020. An Individual Patient Data Meta-Analysis with Colombian Studies on the Effect of Dark Chocolate Consumption on Cardiovascular Risk Parameters. Journal of Nutrition and Metabolism،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188677
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alvarez, Leidy…[et al.]. An Individual Patient Data Meta-Analysis with Colombian Studies on the Effect of Dark Chocolate Consumption on Cardiovascular Risk Parameters. Journal of Nutrition and Metabolism No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1188677
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alvarez, Leidy& Contreras, Javier& Giraldo, Mónica. An Individual Patient Data Meta-Analysis with Colombian Studies on the Effect of Dark Chocolate Consumption on Cardiovascular Risk Parameters. Journal of Nutrition and Metabolism. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1188677
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188677
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر