κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice
المؤلفون المشاركون
Wu, Wei
Zhen, Zhanghe
Niu, Tingting
Zhu, Xiaojuan
Gao, Yuli
Yan, Jiangyan
Chen, Yu
Yan, Xiaojun
Chen, Haimin
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-09
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Background.
The dietary usage of carrageenan as common food additive has increased observably over the last 50 years.
But there is substantial controversy about its safety.
Methods.
We investigated whether the κ-carrageenan could enhance lipopolysaccharide-induced IL-8 expression by studying its actions on the TLR4-NF-κB pathway.
The aggravating effect of κ-carrageenan on Citrobacter freundii DBS100-induced intestinal inflammation was also investigated in a mouse model.
Results.
Our data show that κ-carrageenan pretreatment promoted LPS-induced IL-8 expression in HT-29 cells.
Although CD14, MD-2, and TLR4 were upregulated, the binding of LPS was not enhanced.
However, the pathway of Bcl10-NF-κB was triggered.
Interestingly, κ-carrageenan competitively blocked the binding of FITC-LPS.
Furthermore, pretreatment with κ-carrageenan for one week previous to gavage with C.
freundii DBS100 markedly aggravated weight loss, mortality, and colonic damage.
The secretion of cytokines was unbalanced and the ratio of Tregs was decreased significantly.
In addition, κ-carrageenan, together with C.
freundii DBS100, enhanced the transcription and secretion of TLR4 and NF-κB.
Conclusions.
κ-Carrageenan can synergistically activate LPS-induced inflammatory through the Bcl10-NF-κB pathway, as indicated by its aggravation of C.
freundii DBS100-induced colitis in mice.
General Significance.
Our results suggest that κ-carrageenan serves as a potential inflammatory agent that magnifies existing intestinal inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Wei& Zhen, Zhanghe& Niu, Tingting& Zhu, Xiaojuan& Gao, Yuli& Yan, Jiangyan…[et al.]. 2017. κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice. Mediators of Inflammation،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188788
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Wei…[et al.]. κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice. Mediators of Inflammation No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1188788
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Wei& Zhen, Zhanghe& Niu, Tingting& Zhu, Xiaojuan& Gao, Yuli& Yan, Jiangyan…[et al.]. κ-Carrageenan Enhances Lipopolysaccharide-Induced Interleukin-8 Secretion by Stimulating the Bcl10-NF-κB Pathway in HT-29 Cells and Aggravates C. freundii-Induced Inflammation in Mice. Mediators of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1188788
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188788
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر