The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target
المؤلفون المشاركون
Argenziano, Monica
Toffoli, Giuseppe
Baboci, Lorena
Capolla, Sara
Di Cintio, Federica
Colombo, Federico
Mauro, Prisca
Dal Bo, Michele
Macor, Paolo
Cavalli, Roberta
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-24
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The development of nanostructures for therapeutic purpose is rapidly growing, following the results obtained in vivo in animal models and in the clinical trials.
Unfortunately, the potential therapeutic efficacy is not completely exploited, yet.
This is mainly due to the fast clearance of the nanostructures in the body.
Nanoparticles and the liver have a unique interaction because the liver represents one of the major barriers for drug delivery.
This interaction becomes even more relevant and complex when the drug delivery strategies employing nanostructures are proposed for the therapy of liver diseases, such as hepatocellular carcinoma (HCC).
In this case, the selective delivery of therapeutic nanoparticles to the tumor microenvironment collides with the tendency of nanostructures to be quickly eliminated by the organ.
The design of a new therapeutic approach based on nanoparticles to treat HCC has to particularly take into consideration passive and active mechanisms to avoid or delay liver elimination and to specifically address cancer cells or the cancer microenvironment.
This review will analyze the different aspects concerning the dual role of the liver, both as an organ carrying out a clearance activity for the nanostructures and as target for therapeutic strategies for HCC treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baboci, Lorena& Capolla, Sara& Di Cintio, Federica& Colombo, Federico& Mauro, Prisca& Dal Bo, Michele…[et al.]. 2020. The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target. Journal of Oncology،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188955
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baboci, Lorena…[et al.]. The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target. Journal of Oncology No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1188955
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baboci, Lorena& Capolla, Sara& Di Cintio, Federica& Colombo, Federico& Mauro, Prisca& Dal Bo, Michele…[et al.]. The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target. Journal of Oncology. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1188955
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1188955
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر