Four-Year Outcome of Aflibercept Treatment-Naïve Patients for Neovascular Age-Related Macular Degeneration: Evidence from a Clinical Setting
المؤلفون المشاركون
Tran, Thi Ha Chau
Gayadine-Harricham, Yanel
Rufin, Virginie
Law-Koune, Sandrine
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
The objective of the study is to report 4-year treatment outcome with intravitreal Aflibercept injections for neovascular age-related macular degeneration (nAMD) as first life therapy in real-life.
Patients and Methods.
This is a prospective, monocenter, observational case series analysis.
Data from treatment-naïve patients with nAMD with at least 4 years of follow-up were included in the analysis.
Data including age, gender, and visual acuity measured on Early Treatment of Diabetic Retinopathy Study charts (ETDRS) and injection numbers were recorded.
Spectral domain optical coherence tomography (SD-OCT) data at baseline, month 3, month 6, month 12, year 2, 3, and 4 were also recorded.
Patients were treated with a modified treat and extend (T&E) regimen.
Results.
Of the 48 eyes with nAMD treated, only 31 eyes were available at the 4-year follow-up.
The mean age was 81 ± 8 years.
The VA gain was 7.3 ± 12.7 letters at 1 year 6.5 ± 12.5 letters at 2 years, VA gain 5.2 ± 17 letters at 3 years, and 6.2 ± 18.6 letters at 4 years.
The reduction of central retinal thickness was 118 ± 187 μm at 4 years.
Complete resolution of fluid was obtained in 18/31 eyes.
The total number of injections was 5.7 ± 2.0 during the first year, 2.9 ± 2.9 during the second year, 3.5 ± 3.3 during the third year, and 4.0 ± 3.4 during the fourth year.
The total number of injections was 16 ± 10.6, ranging from 3 to 52 injections.
Ten eyes developed macular atrophy over the 4-year period.
Conclusion.
The results suggest that good long-term morphological and functional outcome can be achieved using Aflibercept in clinical setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gayadine-Harricham, Yanel& Rufin, Virginie& Law-Koune, Sandrine& Tran, Thi Ha Chau. 2020. Four-Year Outcome of Aflibercept Treatment-Naïve Patients for Neovascular Age-Related Macular Degeneration: Evidence from a Clinical Setting. Journal of Ophthalmology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189659
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gayadine-Harricham, Yanel…[et al.]. Four-Year Outcome of Aflibercept Treatment-Naïve Patients for Neovascular Age-Related Macular Degeneration: Evidence from a Clinical Setting. Journal of Ophthalmology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1189659
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gayadine-Harricham, Yanel& Rufin, Virginie& Law-Koune, Sandrine& Tran, Thi Ha Chau. Four-Year Outcome of Aflibercept Treatment-Naïve Patients for Neovascular Age-Related Macular Degeneration: Evidence from a Clinical Setting. Journal of Ophthalmology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1189659
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1189659
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر