Associations of Serological Biomarkers of sICAM-1, IL-1β, MIF, and su-PAR with 3-Month Mortality in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
المؤلفون المشاركون
Xiao, Yonglong
Cai, Hourong
Qiu, Xiaohua
Li, Xuran
Zhou, Ying
Zou, Ruyi
Chen, Haoran
Liu, Xiaoqin
Dai, Jinghong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate prognostic values of serum biomarkers of soluble intercellular adhesion molecule 1 (sICAM-1), macrophage migration inhibitor factor (MIF), interleukin 1β (IL-1β), and soluble urokinase plasminogen activator receptor (su-PAR) in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF).
Methods.
From August 2017 to November 2019, 122 consecutive IPF patients treated in our center were classified as stable IPF and AE-IPF based on the newly published international guidelines.
Serum levels of four biomarkers at admission were measured by the enzyme-linked immunosorbent assay (ELISA).
The primary endpoint was 3-month mortality.
The log-rank test and logistic regression analysis were used to evaluate the effects of these biomarkers for survival in patients with AE-IPF.
Cox proportional hazards analysis was performed to evaluate the prognostic values of serological biomarkers and clinical data.
Results.
Eighty-one patients were diagnosed with stable IPF, and 41 AE-IPF patients were enrolled in the study.
Serum levels of sICAM-1 (p<0.001), IL-1β (p<0.001), MIF (p<0.001), and su-PAR (p<0.001) in patients with IPF were significantly increased compared to those in healthy controls.
All the four biomarkers were elevated in patients with AE-IPF compared to those with stable IPF.
The 3-month mortality in AE-IPF was 56.1% (23/41).
Increased levels of MIF (p=0.01) and IL-1β (>5 pg/mL, p=0.033) were independent risk factors for 3-month mortality in patients with AE-IPF.
Conclusions.
We showed the higher serum levels of IL-1β, and MIF had prognostic values for 3-month mortality in AE-IPF.
This study provided a clue to promote our understanding in the pathogenesis of the disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xuran& Zhou, Ying& Zou, Ruyi& Chen, Haoran& Liu, Xiaoqin& Qiu, Xiaohua…[et al.]. 2020. Associations of Serological Biomarkers of sICAM-1, IL-1β, MIF, and su-PAR with 3-Month Mortality in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xuran…[et al.]. Associations of Serological Biomarkers of sICAM-1, IL-1β, MIF, and su-PAR with 3-Month Mortality in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1191765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xuran& Zhou, Ying& Zou, Ruyi& Chen, Haoran& Liu, Xiaoqin& Qiu, Xiaohua…[et al.]. Associations of Serological Biomarkers of sICAM-1, IL-1β, MIF, and su-PAR with 3-Month Mortality in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1191765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر