Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology
المؤلفون المشاركون
Mehanathan, Pabithadevi B.
Erusan, R. Raskin
Shantaraman, K.
Kannan, S. M.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-21
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Introduction.
Hashimoto’s thyroiditis (HT) is a common autoimmune thyroid disorder, which predominantly presents as a diffuse goiter, with few studies which report HT presenting as multinodular goiter, with variable frequencies ranging from 59% to 78.6% especially from south Indian populations.
This variant clinical presentation may have diagnostic challenges which require further analysis.
Anti-TPO antibodies are more common (90-95%) in Hashimoto’s thyroiditis than anti-TG antibodies in Hashimoto’s thyroiditis.
This study analyzes the clinical features and the correlation of anti-TPO levels with diffuse and multinodular forms of HT.
Material and Methods.
This study was conducted in the Department of General Surgery in a tertiary care hospital in south Tamil Nadu.
Patients presenting with clinical features of a thyroid disorder were interviewed and given a detailed clinical, radiological examination and guided FNAC.
Those patients diagnosed by FNAC as HT were registered and a sample of 3cc of blood was drawn for T3, T4, TSH, and anti-TPO analysis.
All the data were tabulated.
Results and Discussion.
Of the 212 patients who presented with goiters, 96 were diagnosed by FNAC as having a cytological picture suggestive of Hashimoto’s thyroiditis.
Of these 96 patients with HT, 46 (47.9%) were multinodular (HT-MNG), 14 (14.58%) were solitary nodules (HT-SNT), and the remaining 36 (37.5%) were diffuse goiters (HT-D).
Of the 46 patients who are HT-MNG, 36.9% had elevated anti-TPO-Ab (more than 35.0U/l) and 63.1% had normal/lower values (less than 35.0U/l).
But of 36 patients with HT-D, 77.7% had elevated anti-TPO-Ab levels (>35U/l).
Chi square statistics was 15.8346 and the p value is 0.0005 (<.05).
Eight cases of HT-D and 3 cases of HT-MNG had hyperthyroidism and 3 cases of HT-D had hypothyroidism and all other cases were in euthyroid state.
Conclusion.
Patients presenting as multinodular Hashimoto’s thyroiditis have low prevalence of elevated anti-TPO-Ab than diffuse HT which suggests that multinodular form of Hashimoto’s thyroiditis is a unique clinical entity with etiopathogenesis that is at variance with the diffuse form.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mehanathan, Pabithadevi B.& Erusan, R. Raskin& Shantaraman, K.& Kannan, S. M.. 2019. Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology. Journal of Thyroid Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1192432
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mehanathan, Pabithadevi B.…[et al.]. Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology. Journal of Thyroid Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1192432
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mehanathan, Pabithadevi B.& Erusan, R. Raskin& Shantaraman, K.& Kannan, S. M.. Antithyroid Peroxidase Antibodies in Multinodular Hashimoto’s Thyroiditis Indicate a Variant Etiology. Journal of Thyroid Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1192432
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192432
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر