Lipid and Bile Acid Dysmetabolism in Crohn’s Disease

المؤلفون المشاركون

Uchiyama, Koji
Kishi, Hisashi
Komatsu, Wataru
Nagao, Masanori
Ohhira, Shuji
Kobashi, Gen

المصدر

Journal of Immunology Research

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-10-01

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأحياء

الملخص EN

Crohn’s disease is one of the systemic autoimmune diseases.

It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus.

The most affected area by Crohn’s disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed.

Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption.

Therefore, if the terminal ileum is impaired, bile acid malabsorption may occur, which may cause congenital diarrhoea in Crohn’s disease.

Similarly, the impairment of the terminal ileum also induces fatty acid malabsorption, which may influence the role of fatty acids in Crohn’s disease.

In contrast, a recent study reported that multidrug resistance protein 1 (MDR1) regulated effector T-cell function in the ileum from bile acid-driven oxidative stress and MDR1 loss of function in a subset of patients with Crohn’s disease.

However, the role of consumption of fatty acids in Crohn’s disease remains to be fully elucidated.

This review is aimed at providing an overview of some recent developments in research of Crohn’s disease from comprehensive perspective with a focus on the connection between disease location and behaviour, lipid diets, and bile acid malabsorption.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Uchiyama, Koji& Kishi, Hisashi& Komatsu, Wataru& Nagao, Masanori& Ohhira, Shuji& Kobashi, Gen. 2018. Lipid and Bile Acid Dysmetabolism in Crohn’s Disease. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192927

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Uchiyama, Koji…[et al.]. Lipid and Bile Acid Dysmetabolism in Crohn’s Disease. Journal of Immunology Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1192927

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Uchiyama, Koji& Kishi, Hisashi& Komatsu, Wataru& Nagao, Masanori& Ohhira, Shuji& Kobashi, Gen. Lipid and Bile Acid Dysmetabolism in Crohn’s Disease. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192927

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1192927