Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of LynSyk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cells
المؤلفون المشاركون
Park, Kwang-Il
Do, Hyun Ju
Oh, Tae-Woo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study is aimed at determining whether Sesamum indicum Linn.
beneficially influences FcεRI-mediated allergic reactions in RBL-2H3 mast cells; it is also aimed at further investigating Lyn/Fyn and Syk signaling pathways.
To examine the antiallergic effect of Sesamum indicum Linn.
extract (SIE), we treated antigen/immunoglobulin E- (IgE-) sensitized mast cells with extracts of various concentrations.
We examined the degranulation release and concentrations of inflammatory mediators.
Additionally, the expressions of genes involved in the FcεRI and arachidonate signaling pathways were examined.
SIE inhibited the degranulation and secretion of inflammatory mediators in antigen/IgE-sensitized mast cells.
SIE reduced the expressions of FcεRI signaling-related genes, such as Syk, Lyn, and Fyn, and the phosphorylation of extracellular signal-regulated kinase in antigen/IgE-sensitized mast cells.
Additionally, in late allergic responses, SIE reduced PGD2 release and COX-2 and cPLA2 phosphorylation expression in FcεRI-mediated mast cell activation.
Lastly, 250–500 mg/kg SIE significantly attenuated the Ag/IgE-induced passive cutaneous anaphylaxis (PCA) reaction in mice.
The potent effect of SIE on RBL-2H3 mast cell activation indicates that the extract could potentially be used as a novel inhibitor against allergic reactions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Do, Hyun Ju& Oh, Tae-Woo& Park, Kwang-Il. 2019. Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of LynSyk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cells. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192994
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Do, Hyun Ju…[et al.]. Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of LynSyk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cells. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192994
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Do, Hyun Ju& Oh, Tae-Woo& Park, Kwang-Il. Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of LynSyk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cells. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192994
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1192994
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر