Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?
المؤلفون المشاركون
Farronato, Giampietro
Parisi, Luca
Bassani, Barbara
Gini, Elisabetta
Bruno, Antonino
Mortara, Lorenzo
Baci, Denisa
Tremolati, Marco
Fanuli, Matteo
المصدر
Journal of Immunology Research
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-25، 25ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-14
دولة النشر
مصر
عدد الصفحات
25
التخصصات الرئيسية
الملخص EN
Macrophages are key cellular components of the innate immunity, acting as the main player in the first-line defence against the pathogens and modulating homeostatic and inflammatory responses.
Plasticity is a major feature of macrophages resulting in extreme heterogeneity both in normal and in pathological conditions.
Macrophages are not homogenous, and they are generally categorized into two broad but distinct subsets as either classically activated (M1) or alternatively activated (M2).
However, macrophages represent a continuum of highly plastic effector cells, resembling a spectrum of diverse phenotype states.
Induction of specific macrophage functions is closely related to the surrounding environment that acts as a relevant orchestrator of macrophage functions.
This phenomenon, termed polarization, results from cell/cell, cell/molecule interaction, governing macrophage functionality within the hosting tissues.
Here, we summarized relevant cellular and molecular mechanisms driving macrophage polarization in “distant” pathological conditions, such as cancer, type 2 diabetes, atherosclerosis, and periodontitis that share macrophage-driven inflammation as a key feature, playing their dual role as killers (M1-like) and/or builders (M2-like).
We also dissect the physio/pathological consequences related to macrophage polarization within selected chronic inflammatory diseases, placing polarized macrophages as a relevant hallmark, putative biomarkers, and possible target for prevention/therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Parisi, Luca& Gini, Elisabetta& Baci, Denisa& Tremolati, Marco& Fanuli, Matteo& Bassani, Barbara…[et al.]. 2018. Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-25.
https://search.emarefa.net/detail/BIM-1193159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Parisi, Luca…[et al.]. Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?. Journal of Immunology Research No. 2018 (2018), pp.1-25.
https://search.emarefa.net/detail/BIM-1193159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Parisi, Luca& Gini, Elisabetta& Baci, Denisa& Tremolati, Marco& Fanuli, Matteo& Bassani, Barbara…[et al.]. Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-25.
https://search.emarefa.net/detail/BIM-1193159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر