Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment
المؤلفون المشاركون
Maioli, Emanuela
Cervellati, Franco
Cavicchio, Carlotta
Benedusi, Mascia
Pambianchi, Erika
Savelli, Vinno
Calamandrei, Duccio
Maellaro, Emilia
Rispoli, Giorgio
Pecorelli, Alessandra
Giuseppe, Valacchi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
While surgery is the definitive treatment for early-stage melanoma, the current therapies against advanced melanoma do not yet provide an effective, long-lasting control of the lesions and a satisfactory impact on patient survival.
Thus, research is also focused on novel treatments that could potentiate the current therapies.
In the present study, we evaluated the effect of potassium ascorbate with ribose (PAR) treatment on the human melanoma cell line, A375, in 2D and 3D models.
In the 2D model, in line with the current literature, the pharmacological treatment with PAR decreased cell proliferation and viability.
In addition, an increase in Connexin 43 mRNA and protein was observed.
This novel finding was confirmed in PAR-treated melanoma cells cultured in 3D, where an increase in functional gap junctions and a higher spheroid compactness were observed.
Moreover, in the 3D model, a remarkable decrease in the size and volume of spheroids was observed, further supporting the treatment efficacy observed in the 2D model.
In conclusion, our results suggest that PAR could be used as a safe adjuvant approach in support to conventional therapies for the treatment of melanoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cavicchio, Carlotta& Benedusi, Mascia& Pambianchi, Erika& Pecorelli, Alessandra& Cervellati, Franco& Savelli, Vinno…[et al.]. 2017. Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cavicchio, Carlotta…[et al.]. Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cavicchio, Carlotta& Benedusi, Mascia& Pambianchi, Erika& Pecorelli, Alessandra& Cervellati, Franco& Savelli, Vinno…[et al.]. Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر