Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells
المؤلفون المشاركون
Chuang, Kai-An
Li, Ming-Han
Lin, Ni-Hsuan
Chang, Chih-Hsuan
Takahashi, Tomoya
Perng, Ming-Der
Wen, Shu-Fang
Lu, I-Huang
Pan, I-Horng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-18
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Neuroinflammation plays a central role in the pathophysiology of Alzheimer’s disease (AD).
Compounds that suppress neuroinflammation have been identified as potential therapeutic targets for AD.
Rhinacanthin C (RC), a naphthoquinone ester found in Rhinacanthus nasutus Kurz (Acanthaceae), is currently proposed as an effective molecule against inflammation.
However, the exact role of RC on neuroinflammation remains to be elucidated.
In the present study, we investigated RC effect on modulating lipopolysaccharides (LPS), amyloid-β peptide (Aβ), or interferon-γ- (IFN-γ-) evoked pathological events in neurons and glia.
Our findings demonstrated that RC prevented Aβ-induced toxicity in rat hippocampal neurons and attenuated LPS-activated nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) expression, and NF-κB signaling in rat glia.
Likewise, RC suppressed LPS-induced neuroinflammation by reducing NO production and iNOS, IL-1β, CCL-2, and CCL-5 mRNA levels in rat microglia.
Further studies using BV-2 microglia revealed that RC inhibited LPS-, Aβ-, and IFN-γ-stimulated IL-6 and TNF-α secretion.
Of note, NF-κB and ERK activation was abrogated by RC in BV-2 cell response to Aβ or IFN-γ.
Moreover, RC protected neurons from Aβ-stimulated microglial conditioned media-dependent toxicity.
Collectively, these data highlight the beneficial effects of RC on neuroprotection and support the therapeutic implications of RC to neuroinflammation-mediated conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chuang, Kai-An& Li, Ming-Han& Lin, Ni-Hsuan& Chang, Chih-Hsuan& Lu, I-Huang& Pan, I-Horng…[et al.]. 2017. Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194960
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chuang, Kai-An…[et al.]. Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1194960
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chuang, Kai-An& Li, Ming-Han& Lin, Ni-Hsuan& Chang, Chih-Hsuan& Lu, I-Huang& Pan, I-Horng…[et al.]. Rhinacanthin C Alleviates Amyloid-β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid-β, and Interferon-γ in Glial Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194960
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194960
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر