Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer
المؤلفون المشاركون
Alio, Jorge L.
Zarnowski, Tomasz
Wróbel-Dudzińska, Dominika
Kosior-Jarecka, Ewa
Rodriguez, Alejandra E.
Suchodoła-Ratajewicz, Ewa
Rymgayłło-Jankowska, Beata
Ćwiklińska-Haszcz, Agnieszka
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
Platelet-rich plasma (PRP) is an autologous blood product without preservatives and rich in proteins and growth factors which make it possible for cells to differentiate, proliferate, and migrate, thus stimulating healing and regeneration of tissues.
The aim of this study was to evaluate the efficiency of autologous platelet-rich plasma in the treatment of neurotrophic keratopathy.
Methods.
The study group consists of 25 patients with nonhealing corneal ulcers due to herpes simplex or herpes zoster infection and facial nerve or trigeminal nerve paralysis as a result of a neurosurgical operation caused by a tumour or stroke.
The patients were given autologous platelet-rich plasma drops five times a day and additionally preservative-free artificial tears and a vitamin A ointment at night for maximum 3 months.
The following were evaluated: best corrected visual acuity (BCVA), healing of corneal surface, subjective symptoms, and changes in corneal thickness with the use of anterior segment optical coherent tomography (AS-OCT).
Results.
BCVA before the treatment was 0.10 ± 0.14, and after the treatment it was –0.3 ± 0.27 (p=0.001).
Improved visual acuity and less subjective symptoms were observed in all patients.
Complete healing of the ulceration was observed in 20 patients (80%).
Four patients (16%) experienced considerable improvement of their clinical condition (reduced size and depth of the ulceration and inflammatory state: smaller conjunctival injection and swelling, improved visual acuity, and less subjective symptoms).
In one of the patients, an amniotic membrane was transplanted due to the lack of improvement of his local condition.
In all patients, the progression of corneal thinning was stopped.
An average corneal thickness in its thinnest point was 322.3 ± 125.8 µm before the treatment, and 404.5 ± 118.7 µm (p<0.05) after the treatment.
None of the patients reported general or local side effects of the treatment.
Conclusions.
Autologous platelet-rich plasma is a blood-based product which seems efficient in the treatment of neurotrophic keratopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wróbel-Dudzińska, Dominika& Alio, Jorge L.& Rodriguez, Alejandra E.& Suchodoła-Ratajewicz, Ewa& Kosior-Jarecka, Ewa& Rymgayłło-Jankowska, Beata…[et al.]. 2018. Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196469
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wróbel-Dudzińska, Dominika…[et al.]. Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer. Journal of Ophthalmology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1196469
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wróbel-Dudzińska, Dominika& Alio, Jorge L.& Rodriguez, Alejandra E.& Suchodoła-Ratajewicz, Ewa& Kosior-Jarecka, Ewa& Rymgayłło-Jankowska, Beata…[et al.]. Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196469
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196469
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر