Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients
المؤلفون المشاركون
Buhmann, Carsten
Poetter-Nerger, Monika
Gulberti, Alessandro
Gerloff, Christian
Hamel, Wolfgang
Hidding, U.
Horn, A.
Koeppen, J. A.
Westphal, M.
Engel, A. K.
Weiss, D.
Moll, C. K. E.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The goal of the study was to compare the tolerability and the effects of conventional subthalamic nucleus (STN) and combined subthalamic nucleus and substantia nigra (STN+SNr) high-frequency stimulation in regard to neuropsychiatric symptoms in Parkinson’s disease patients.
In this single center, randomized, double-blind, cross-over clinical trial, twelve patients with advanced Parkinson’s disease (1 female; age: 61.3±7.3 years; disease duration: 12.3±5.4 years; Hoehn and Yahr stage: 2.2±0.39) were included.
Apathy, fatigue, depression, and impulse control disorder were assessed using a comprehensive set of standardized rating scales and questionnaires such as the Lille Apathy Rating Scale (LARS), Modified Fatigue Impact Scale (MFIS), Becks Depression Inventory (BDI-I), Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease Rating Scale (QUIP-RS), and Parkinson’s Disease Questionnaire (PDQ-39).
Three patients that were initially assigned to the STN+SNr stimulation mode withdrew from the study within the first week due to discomfort.
Statistical comparison of data retrieved from patients who completed the study revealed no significant differences between both stimulation conditions in terms of mean scores of scales measuring apathy, fatigue, depression, impulse control disorder, and quality of life.
Individual cases showed an improvement of apathy under combined STN+SNr stimulation.
In general, combined STN+SNr stimulation seems to be safe in terms of neuropsychiatric side effects, although careful patient selection and monitoring in the short-term period after changing stimulation settings are recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hidding, U.& Gulberti, Alessandro& Horn, A.& Buhmann, Carsten& Hamel, Wolfgang& Koeppen, J. A.…[et al.]. 2017. Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197119
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hidding, U.…[et al.]. Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients. Parkinson’s Disease No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1197119
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hidding, U.& Gulberti, Alessandro& Horn, A.& Buhmann, Carsten& Hamel, Wolfgang& Koeppen, J. A.…[et al.]. Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197119
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197119
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر