Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition

المؤلفون المشاركون

Pal, Rahul
Singh, Sarman
Sabareesh, Varatharajan
Kumar, Parveen
Fatima, Zeeshan
Hameed, Saif

المصدر

Journal of Pathogens

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-06-19

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Many of the earlier studies involving the effect of isoniazid (INH) treatment have solely focused on the fatty acyl (FA) category of Mycobacterium tuberculosis (MTB) lipids.

This motivated us with the major interest to examine the impact of INH on various other categories of MTB lipids.

Towards this, we chose to interpret our mass spectral data (LC-ESI-MS) by a standalone software, MS-LAMP, in which “Mtb LipidDB” was integrated.

Analysis by MS-LAMP revealed that INH treatment can alter the composition of “glycerolipids (GLs)” and “glycerophospholipids (GPLs)” categories of MTB lipids, in addition to the variations to FA category.

Interpretation by “MycoMass” database yielded similar results as that of Mtb LipidDB, except that significant alterations to polyketides (PKs) category also were observed.

Probing biosynthetic pathways of certain key lipids belonging to any of GLs, GPLs, and PKs categories can be attractive target(s) for drug discovery or can be useful to identify means to overcome drug resistance or to obtain insights into the causal factors of virulence.

To the best of our knowledge, this is the first report hinting at the influence of INH on GLs, GPLs, and PKs of MTB.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Pal, Rahul& Hameed, Saif& Sabareesh, Varatharajan& Kumar, Parveen& Singh, Sarman& Fatima, Zeeshan. 2018. Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. Journal of Pathogens،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1197464

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Pal, Rahul…[et al.]. Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. Journal of Pathogens No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1197464

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Pal, Rahul& Hameed, Saif& Sabareesh, Varatharajan& Kumar, Parveen& Singh, Sarman& Fatima, Zeeshan. Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. Journal of Pathogens. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1197464

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1197464