Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition
المؤلفون المشاركون
Pal, Rahul
Singh, Sarman
Sabareesh, Varatharajan
Kumar, Parveen
Fatima, Zeeshan
Hameed, Saif
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Many of the earlier studies involving the effect of isoniazid (INH) treatment have solely focused on the fatty acyl (FA) category of Mycobacterium tuberculosis (MTB) lipids.
This motivated us with the major interest to examine the impact of INH on various other categories of MTB lipids.
Towards this, we chose to interpret our mass spectral data (LC-ESI-MS) by a standalone software, MS-LAMP, in which “Mtb LipidDB” was integrated.
Analysis by MS-LAMP revealed that INH treatment can alter the composition of “glycerolipids (GLs)” and “glycerophospholipids (GPLs)” categories of MTB lipids, in addition to the variations to FA category.
Interpretation by “MycoMass” database yielded similar results as that of Mtb LipidDB, except that significant alterations to polyketides (PKs) category also were observed.
Probing biosynthetic pathways of certain key lipids belonging to any of GLs, GPLs, and PKs categories can be attractive target(s) for drug discovery or can be useful to identify means to overcome drug resistance or to obtain insights into the causal factors of virulence.
To the best of our knowledge, this is the first report hinting at the influence of INH on GLs, GPLs, and PKs of MTB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pal, Rahul& Hameed, Saif& Sabareesh, Varatharajan& Kumar, Parveen& Singh, Sarman& Fatima, Zeeshan. 2018. Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. Journal of Pathogens،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1197464
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pal, Rahul…[et al.]. Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. Journal of Pathogens No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1197464
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pal, Rahul& Hameed, Saif& Sabareesh, Varatharajan& Kumar, Parveen& Singh, Sarman& Fatima, Zeeshan. Investigations into Isoniazid Treated Mycobacterium tuberculosis by Electrospray Mass Spectrometry Reveals New Insights into Its Lipid Composition. Journal of Pathogens. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1197464
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197464
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر