The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies
المؤلفون المشاركون
Ejiofor, Obiora Shedrach
Ajunwa, Onyinye Mercy
Ezeudu, Chijioke Elias
Emechebe, George Ogonna
Okeke, Kenneth Nchekwube
Ifezulike, Christian Chukwuemeka
Ekejindu, Ifeoma Mercy
Okoyeh, Jude Nnaemeka
Osuala, Eunice Ogonna
Oli, Angus Nnamdi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Neonatal infection refers to the infection of the newborn during the first twenty-eight days of life.
It is one of the causes of infant morbidity and mortality worldwide.
The aim of the study is to determine the relative contribution of the different pathogens to the overall disease burden.
It will also determine the mechanisms of virulence of these pathogens that cause neonatal infections at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH), Awka.
Methods.
Biological samples were collected from 30 neonates admitted at the special care baby unit (SCBU) of COOUTH and cultured using selective media and nutrient agar.
The isolates were identified using microbiological and biochemical tests.
The antibiogram study was determined using Kirby-Bauer disc diffusion method on Mueller Hinton Agar.
Several methods previously reported in literature were used for the characterization of the virulence factors.
Results.
From the 30 blood samples collected, Pseudomonas spp.
(19.7%), Escherichia coli (23%), Salmonella spp.
(24.6%), and Staphylococcus aureus (32.8%) were isolated.
Male to female ratio of study population was 1.5: 1.
The isolates were 100 % resistant to ticarcillin, cephalothin, ceftazidime, and cefuroxime but appreciably susceptible to only levofloxacin (88.85%).
They were moderately susceptible to ceftriaxone/sulbactam (39.05%) and azithromycin (26.46%).
Common virulence factors identified among the isolates (up to 90 %) were hemolysin, biofilm formation, and acid resistance.
Less common virulence factors were proteases (50 %), deoxyribonucleases (50 %), enterotoxins (63%), and lipopolysaccharide (70%).
The virulence factors were found mostly among the S.
aureus isolates.
Conclusions.
Pseudomonas spp., Escherichia coli, Salmonella spp., and Staphylococcus aureus were implicated in neonatal infections in the center and most of them were resistant to conventional antibiotics.
The organisms showed marked virulence and multidrug resistance properties.
Levofloxacin, a fluoroquinolone, had superior activity on the isolates compared to other antibiotics used in the study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ejiofor, Obiora Shedrach& Ajunwa, Onyinye Mercy& Ezeudu, Chijioke Elias& Emechebe, George Ogonna& Okeke, Kenneth Nchekwube& Ifezulike, Christian Chukwuemeka…[et al.]. 2018. The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies. Journal of Pathogens،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1197498
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ejiofor, Obiora Shedrach…[et al.]. The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies. Journal of Pathogens No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1197498
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ejiofor, Obiora Shedrach& Ajunwa, Onyinye Mercy& Ezeudu, Chijioke Elias& Emechebe, George Ogonna& Okeke, Kenneth Nchekwube& Ifezulike, Christian Chukwuemeka…[et al.]. The Bacteriology and Its Virulence Factors in Neonatal Infections: Threats to Child Survival Strategies. Journal of Pathogens. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1197498
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197498
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر