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Effects of Tumor Necrosis Factor-α on Morphology and Mechanical Properties of HCT116 Human Colon Cancer Cells Investigated by Atomic Force Microscopy
المؤلفون المشاركون
Liu, Huiqing
Wang, Nan
Zhang, Zhe
Wang, Hongda
Tang, Jilin
Du, Jun
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Chronic inflammation orchestrates the tumor microenvironment and is strongly associated with cancer.
Tumor necrosis factor-α (TNFα) is involved in tumor invasion and metastasis by inducing epithelial to mesenchymal transition (EMT).
This process is defined by the loss of epithelial characteristics and gain of mesenchymal traits.
The mechanisms of TNFα-induced EMT in cancer cells have been well studied.
However, mechanical properties have not yet been probed.
In this work, atomic force microscopy (AFM) was applied to investigate the morphology and mechanical properties of EMT in HCT116 human colon cancer cells.
A remarkable morphological change from cobblestone shape to spindle-like morphology was observed.
In parallel, AFM images showed that the cellular cytoskeleton was rearranged from a cortical to a stress-fiber pattern.
Moreover, cell stiffness measurements indicated that Young’s modulus of cells gradually reduced from 1 to 3 days with TNFα-treatment, but it has an apparent increase after 4 days of treatment compared with that for 3 days.
Additionally, Young’s modulus of the cells treated with TNFα for 4 days is slightly larger than that for 1 or 2 days, but still less than that of the untreated cells.
Our work contributes to a better understanding of colorectal cancer metastasis induced by inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Huiqing& Wang, Nan& Zhang, Zhe& Wang, Hongda& Du, Jun& Tang, Jilin. 2017. Effects of Tumor Necrosis Factor-α on Morphology and Mechanical Properties of HCT116 Human Colon Cancer Cells Investigated by Atomic Force Microscopy. Scanning،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197839
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Huiqing…[et al.]. Effects of Tumor Necrosis Factor-α on Morphology and Mechanical Properties of HCT116 Human Colon Cancer Cells Investigated by Atomic Force Microscopy. Scanning No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1197839
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Huiqing& Wang, Nan& Zhang, Zhe& Wang, Hongda& Du, Jun& Tang, Jilin. Effects of Tumor Necrosis Factor-α on Morphology and Mechanical Properties of HCT116 Human Colon Cancer Cells Investigated by Atomic Force Microscopy. Scanning. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1197839
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197839
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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