β-Arrestin1miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest
المؤلفون المشاركون
Tafani, M.
Catanzaro, Giuseppina
Besharat, Zein Mersini
Alfano, Vincenzo
Po, Agnese
Ferretti, Elisabetta
Abballe, Luana
Vacca, Alessandra
Begalli, Federica
Napolitano, Maddalena
Giangaspero, Felice
Miele, E.
Locatelli, Franco
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-12
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Cell development is regulated by a complex network of mRNA-encoded proteins and microRNAs, all funnelling onto the modulation of self-renewal or differentiation genes.
How intragenic microRNAs and their host genes are transcriptionally coregulated and their functional relationships for the control of neural stem cells (NSCs) are poorly understood.
We propose here the intragenic miR-326 and its host gene β-arrestin1 as novel players whose epigenetic silencing maintains stemness in normal cerebellar stem cells.
Such a regulation is mediated by CpG islands methylation of the common promoter.
Epigenetic derepression of β-arrestin1/miR-326 by differentiation signals or demethylating agents leads to suppression of stemness features and cell growth and promotes cell differentiation.
β-Arrestin1 inhibits cell proliferation by enhancing the nuclear expression of the cyclin-dependent kinase inhibitor p27.
Therefore, we propose a new mechanism for the control of cerebellar NSCs where a coordinated epigenetic mechanism finely regulates β-arrestin1/miR-326 expression and consequently NSCs stemness and cell growth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Po, Agnese& Begalli, Federica& Abballe, Luana& Alfano, Vincenzo& Besharat, Zein Mersini& Catanzaro, Giuseppina…[et al.]. 2017. β-Arrestin1miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201762
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Po, Agnese…[et al.]. β-Arrestin1miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1201762
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Po, Agnese& Begalli, Federica& Abballe, Luana& Alfano, Vincenzo& Besharat, Zein Mersini& Catanzaro, Giuseppina…[et al.]. β-Arrestin1miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201762
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201762
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر