TNFα-Mediated Necroptosis Aggravates Ischemia-Reperfusion Injury in the Fatty Liver by Regulating the Inflammatory Response
المؤلفون المشاركون
Ren, Hao-zhen
Shi, Xiao-lei
Yang, Faji
Shang, Longcheng
Wang, Shuai
Liu, Yang
Zhu, Wei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-12
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Nonalcoholic fatty liver disease (NAFLD) is more sensitive to ischemia and reperfusion injury (IRI), while there are no effective methods to alleviate IRI.
Necroptosis, also known as “programmed necrosis,” incorporates features of necrosis and apoptosis.
However, the role of necroptosis in IRI of the fatty liver remains largely unexplored.
In the present study, we aimed to assess whether necroptosis was activated in the fatty liver and whether such activation accelerated IRI in the fatty liver.
In this study, we found that the liver IRI was enhanced in HFD-fed mice with more release of TNFα.
TNFα and supernatant of macrophages could induce necroptosis of hepatocytes in vitro.
Necroptosis was activated in NAFLD, leading to more severe IRI, and such necroptosis could be inhibited by TN3-19.12, the neutralizing monoclonal antibody against TNFα.
Pretreatment with Nec-1 and GSK′872, two inhibitors of necroptosis, significantly reduced the liver IRI and ROS production in HFD-fed mice.
Moreover, the inhibition of necroptosis could decrease ROS production of hepatocytes in vitro.
Inflammatory response was activated during IRI, and necroptosis inhibitors could suppress signaling pathways of inflammation and the soakage of inflammation cells.
In conclusion, TNFα-induced necroptosis played an important role during IRI in the fatty liver.
Our findings demonstrated that necroptosis might be a potential target to reduce the fatty liver-associated IRI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Faji& Shang, Longcheng& Wang, Shuai& Liu, Yang& Ren, Hao-zhen& Zhu, Wei…[et al.]. 2019. TNFα-Mediated Necroptosis Aggravates Ischemia-Reperfusion Injury in the Fatty Liver by Regulating the Inflammatory Response. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202564
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Faji…[et al.]. TNFα-Mediated Necroptosis Aggravates Ischemia-Reperfusion Injury in the Fatty Liver by Regulating the Inflammatory Response. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1202564
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Faji& Shang, Longcheng& Wang, Shuai& Liu, Yang& Ren, Hao-zhen& Zhu, Wei…[et al.]. TNFα-Mediated Necroptosis Aggravates Ischemia-Reperfusion Injury in the Fatty Liver by Regulating the Inflammatory Response. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1202564
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202564
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر