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Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons
المؤلفون المشاركون
Park, Chul-Kyu
Im, Sang-Taek
Jo, Youn Yi
Han, Gayoung
Jo, Hyun Jung
Kim, Yong Ho
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-02
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Dexmedetomidine, an α2-adrenoceptor agonist, is widely used as a sedative and analgesic agent in a number of clinical applications.
However, little is known about the mechanism by which it exerts its analgesic effects on the trigeminal system.
Two types of voltage-gated sodium channels, Nav1.7 and Nav1.8, as well as α2-adrenoceptors are expressed in primary sensory neurons of the trigeminal ganglion (TG).
Using whole-cell patch-clamp recordings, we investigated the effects of dexmedetomidine on voltage-gated sodium channel currents (INa) via α2-adrenoceptors in dissociated, small-sized TG neurons.
Dexmedetomidine caused a concentration-dependent inhibition of INa in small-sized TG neurons.
INa inhibition by dexmedetomidine was blocked by yohimbine, a competitive α2-adrenoceptor antagonist.
Dexmedetomidine-induced inhibition of INa was mediated by G protein-coupled receptors (GPCRs) as this effect was blocked by intracellular perfusion with the G protein inhibitor GDPβ-S.
Our results suggest that the INa inhibition in small-sized TG neurons, mediated by the activation of Gi/o protein-coupled α2-adrenoceptors, might contribute to the analgesic effects of dexmedetomidine in the trigeminal system.
Therefore, these new findings highlight a potential novel target for analgesic drugs in the orofacial region.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Im, Sang-Taek& Jo, Youn Yi& Han, Gayoung& Jo, Hyun Jung& Kim, Yong Ho& Park, Chul-Kyu. 2018. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203365
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Im, Sang-Taek…[et al.]. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators of Inflammation No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1203365
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Im, Sang-Taek& Jo, Youn Yi& Han, Gayoung& Jo, Hyun Jung& Kim, Yong Ho& Park, Chul-Kyu. Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1203365
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203365
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